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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Summary of major classes of drug and the Cytochrome enzyme/transport protein involved during adverse events

From: Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

Drug/class

Cytochrome enzyme/transport protein involved

Effect of interaction

Digoxin/cardiac glycoside

P-gp

Decreases drug AUC by 25-30 %

Nifedipine/calcium channel blocker

CYP3A4, P-gp

Decreases drug AUC by 45 %

Simvastatin/antihyperlipidemic

CYP3A4

Decreases drug AUC by 50 %

Warfarin/anticoagulant

CYP2C9

Loss of efficacy due to decrease in INR

  1. Adapted from [23]
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