Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of aqueous leaf extract of Costus afer and silymarin on antioxidant parameter

Treatments	GSH (μg/mg protein)	MDA (μmol/mg)	Catalase (μg/mg protein)	GPA ((μg/mg protein))	SOD ((μg/mg protein))	GST ((μg/mg protein))
NC (water)	0.04±0.001^bc	0.04± 0.002^c	0.13±0.01	0.12±0.006	0.06±0.003^bc	0.83±0.006^ab
TC (CsA (50 mg/kg)	0.03±0.001^ac	0.05±0.004^c	0.11±0.01	0.12±0.006	0.05±0.002^ac	0.82±0.012^ac
CsA+ 375 mg/kg CA Extract	0.04±0.002^bc	0.03±.005^ab	0.13±0.01	0.12±0E-7^b	0.05±0.001^a	0.76±0.006^abc
CsA+ 750 mg/kg CA Extract	0.034±0.001^ac	0.03±0.003^ab	0.13±0.01	0.13±0.006^b	0.05±0.001^a	0.80±0.006^bc
CsA+ 1125 mg/kg CA Extract	0.046±0.002^b	0.02±0.001^acb	0.14±0.01^b	0.13±0.006	0.05±0.006^ab	0.82±0.006^b
CsA+ Silymarin (100 mg/kg)	0.047±0.001^ab	0.03±0.001^ab	0.13±0.01	0.11 ± 0.006	0.05 ± 0.003^ab	0.82±0.006^b

All values represent Mean ± SD (n=5); a = p<0.05 vs NC; b = p<0.05 TC; c= p<0.05 vs Silymarin. NC normal control, TC toxic control