International Journal of Phytomedicine and Phytotherapy
Table 2 Analysis of oral drug-likeness of the six bioactive compounds using Lipinski’s rule of five
Bioactive Compounds | Molecular weight (g/mol) | Log P | Number of hydrogen bond donor | Number of hydrogen bond acceptor | Molar refractivity |
|---|---|---|---|---|---|
Caffeic acid | 180.16 | 0.97 | 3 | 4 | 47.16 |
Gallic acid | 170.12 | 0.21 | 4 | 5 | 38.47 |
Metformin | 129.16 | 0.34 | 3 | 2 | 36.93 |
Quercetin | 302.24 | 1.63 | 5 | 7 | 78.04 |
Rutin | 617.66 | − 92.39 | 10 | 14 | 147.66 |
Chlorogenic acid | 354.31 | 0.87 | 6 | 9 | 83.50 |
Kaempferol | 286.24 | 1.70 | 4 | 6 | 76.01 |