Cardioprotective effects of Rhododendron arboreum leaf extract against Doxorubicin-induced cardiotoxicity in Wistar rats by modulating electrocardiographic and cardiac biomarkers

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of Rhododendron arboreum leaf extract on various serum biomarker levels of Wistar rats (N-6)

SL.NO	Treatment groups	AST (U/L)	ALT (U/L)	CK-MB (U/L)	CK-NAC (U/L)	LDH (U/L)
1.	Normal control	15.49 ± 0.04	19.41 ± 0.04	76.60 ± 0.03	44.76 ± 0.11	121.4 ± 0.01
2.	DOX control	44.33 ± 1.05^***	44.65 ± 1.44^***	210.2 ± 0.32^***	143.2 ± 2.03^***	205.7 ± 1.28^***
3.	RALD-100 mg/kg	36.70 ± 0.95^***###	32.88 ± 0.78^***###	180.0 ± 0.45^***###	79.85 ± 2.45^***###	165.9 ± 0.25^***###
4.	RAHD-250 mg/kg	25.56 ± 0.64^***###	26.14 ± 1.08^***###	146.9 ± 0.51^***###	65.97 ± 1.16^***###	134.2 ± 4.35^**###

Values are expressed as mean ± SEM, n = 6, ^***P < 0.001, ^**P < 0.01when compared to a normal group; ^###P < 0.001 compared to a DOX control group
DOX Doxorubicin, RALD Rhododendron arboreum low dose, RAHD Rhododendron arboreum high dose, ALT Alanine aminotransferase, AST Aspartate aminotransferase, CK-MB Creatine kinase-MB, CK-NAC Creatine kinase-N-acetyltransferase, LDH Lactate dehydrogenase