Table 3 In vivo anti-ulcer activity of medicinal plant in Ethiopia

(Abebaw, Mishra et al. 2017) [1]

Osyris quadripartita Decne.(Santalaceae)

Pylorus ligation induced Wistar albino rats

Methanol

20 days

200 mg/kg = 68.42

200 mg/kg = 1.5%

Ethanol-induced ulcer models Wistar albino rats

20 days

200 mg/kg = 85.35

200 mg/kg = −4.1%

(Adane, Atnafie et al. 2021) [2]

Ficus thonningii (Moraceae)

Pylorus ligation

Hydromethanol

10 days

100 mg/kg = 33.6

200 mg/kg = 59.07

400 mg/kg = 62.1

100 mg/kg = −14.7

200 mg/kg = 10.57

400 mg/kg = 13.6

Ethanol-induced ulcer rodent models

Hydromethanol

10 days

100 mg/kg = 71.86

100 mg/kg = −1.1

Chloroform fraction

10 days

200 mg/kg = 39.16

200 mg/kg = −33.2

Aqueous fraction

10 days

200 mg/kg = 70.76

200 mg/kg = −2.2

Indomethacin induced

Hydromethanol

4 days

100 mg/kg = 55.02

200 mg/kg = 61.15

400 mg/kg = 63.35

100 mg/kg = − 44.98

200 mg/kg = − 38.85

400 mg/kg = − 36.65

(Belayneh, Amare et al. 2021) [9]

Solanum incanum L. (Solanaceae)

Pylorus ligation-induced model

Hydromethanol

10 days

Leaf 100 mg/kg = 5.83

200 mg/kg = 34.17

400 mg/kg = 48.83

Root 100 mg/kg = 27.83

200 mg/kg = 30.5

400 mg/kg = 48.67

Leaf 100 mg/kg = − 48.67

200 mg/kg = − 20.33

400 mg/kg = − 5.67

Root 100 mg/kg = − 26.6

200 mg/kg = − 24

400 mg/kg = − 5.83

Ethanol-induced Mice ulcer

Hydromethanol

10 days

Leaf 100 mg/kg = 35.43

200 mg/kg = 44.88

400 mg/kg = 52.36

Root 100 mg/kg = 36.02

200 mg/kg = 42.32

400 mg/kg = 52.36

Leaf 100 mg/kg = − 37.4

200 mg/kg = − 27.95

400 mg/kg = − 20.47

Root 100 mg/kg = − 36.81

200 mg/kg = − 30.51

400 mg/kg = − 20.47

(Mekonnen, Asrade Atnafie et al. 2020) [27]

Crotonmacrostachyus Hocsht:Ex

Del. (Euphorbiaceae)

Acidified Ethanol-induced Mice ulcer

Methanol

7 days

100 mg/kg = 24.44

200 mg/kg = 45.93

400 mg/kg = 62.22

100 mg/kg = − 55.56

200 mg/kg = − 34.07

400 mg/kg = − 17.78

Chloroform

7 days

100 mg/kg = 53

200 mg/kg = 68.8

400 mg/kg = 78.1

100 mg/kg = − 28.4

200 mg/kg = − 12.6

400 mg/kg = − 3.3

Ethyl acetate fraction

7 days

100 mg/kg = 18.6

200 mg/kg = 46.6

400 mg/kg = 62.8

100 mg/kg = − 62.8

200 mg/kg = − 34.8

400 mg/kg = − 18.8

Aqueous fraction

7 days

100 mg/kg = 11.7

200 mg/kg = 11.32

400 mg/kg = 21.4

100 mg/kg = − 69.7

200 mg/kg = − 70.08

400 mg/kg = − 60

(Melese, Asres et al. 2011) [28]

Plantago lanceolata L

Indomethacin induced

aqueous extract

4 hrs

200 mg/kg = 27.3

400 mg/kg = 86.4

200 mg/kg = − 40.9

400 mg/kg = 18.2

cysteamine induced

aqueous extract

24 hrs

200 mg/kg = 40

400 mg/kg = 60

200 mg/kg = − 33.3

400 mg/kg = − 13.3

Acetic acid-induced

Aqueous extract

10 days

200 mg/kg = 50.9

400 mg/kg = 77.9

200 mg/kg = − 25.3

400 mg/kg = 1.7

Mequanente, Makonnen et al. 2006 [29]

Trigonella feonum-gracum

Indomethacin-induced

Aqueous extract

6 hrs

500 mg/kg = 33.6

1000 mg/kg = 59.9

1500 mg/kg = 65.5

500 mg/kg = − 20.8

1000 mg/kg = 5.5

1500 mg/kg = 11.1

Linum ussitatissimum

Indomethacin-induced

Aqueous extract

6 hrs

500 mg/kg = 42

1000 mg/kg = 58.6

1500 mg/kg = 67.8

500 mg/kg = − 12.4

1000 mg/kg = 4.2

1500 mg/kg = 13.4

(Noamesi, Mensah et al. 1994) [35]

Taverniera abyssinica A.

Ethanol induced

Aqueous extract

4 days

125 mg/kg = 54

250 mg/kg = 58

500 mg/kg = 80

(Sisay, Andargie et al. 2021) [44]

Urtica simensis Hochst. ex. A. Rich. (Urticaceae)

pylorus-ligated rats.

Hydromethanolic

10 days

100 mg/kg = 50.34

200 mg/kg = 59.88

400 mg/kg = 67.68

100 mg/kg = − 16.96

200 mg/kg = − 7.32

400 mg/kg = 0.38

Cold restraint stress-induced ulcerated rats.

Hydromethanolic

3 hrs

100 mg/kg = 33.77

200 mg/kg = 49.93

400 mg/kg = 53.22

100 mg/kg = −8.08

200 mg/kg = − 12.37

400 mg/kg = − 27.53

acetic acid-induced ulcer in rats

Hydromethanolic

20 days

100 mg/kg = 33.54

200 mg/kg = 58.34

400 mg/kg = 67.07

100 mg/kg = − 30.79

200 mg/kg = − 6

400 mg/kg = 2.76

(Sisay Zewdu and Jemere Aragaw 2021) [45]

Rumex nepalensis

Pyloric ligation Rats

Hydromethanolic

10 days

100 mg/kg = 51.17

200 mg/kg = 59.78

400 mg/kg = 67.52

100 mg/kg = − 16.18

200 mg/kg = − 7.57

400 mg/kg = 0.17

Chloroform

Fraction

10 days

100 mg/kg = 2.54

200 mg/kg = 4.4

400 mg/kg = 8.6

100 mg/kg = − 67.36

200 mg/kg = − 65.5

400 mg/kg = − 61.3

Ethyl acetate

Fraction

10 days

100 mg/kg = 53.26

200 mg/kg = 61.4

400 mg/kg = 69.26

100 mg/kg = − 16.64

200 mg/kg = − 8.5

400 mg/kg = − 0.64

Aqueous fraction

10 days

100 mg/kg = 45.69

200 mg/kg = 55.6

400 mg/kg = 58.23

100 mg/kg = − 24.21

200 mg/kg = − 14.3

400 mg/kg = − 11.67

Acetic acid-induced ulcer Rats

Hydromethanolic

15 days

100 mg/kg = 26.1

200 mg/kg = 51.82

400 mg/kg = 54.59

100 mg/kg = − 36.94

200 mg/kg = − 9.82

400 mg/kg = − 8.45

(Yismaw, Abdelwuhab et al. 2020) [50]

Cordia africana Lam Boraginaceae)

Pyloric Ligated Rats

Methanol

10 days

600 mg/kg = 59.73

600 mg/kg = − 0.28

(Hailu 2021) [20]

Ensete ventricosum (Welw.) Cheesman (Musaceae)

Indomethacin induced Rat

Aqueous extract

6 hrs

100 mg/kg = 25.8

200 mg/kg = 42.3

400 mg/kg = 71.7

100 mg/kg = − 73.5

200 mg/kg = − 57

400 mg/kg = − 27.6

Ethanol-induced Rat

Aqueous extract

1 hr.

100 mg/kg = 24.24

200 mg/kg = 41.6

400 mg/kg = 55.04

100 mg/kg = − 46.08

200 mg/kg = − 28.72

400 mg/kg = − 15.28

Pyloric Ligated Rats

Aqueous extract

4 hrs

100 mg/kg = 40.07

200 mg/kg = 60.38

400 mg/kg = 98.53

100 mg/kg = − 59.53

200 mg/kg = − 39.22

400 mg/kg = − 1.07

(Ahmed 2019) [3]

Urtica simensis

Pyloric Ligated Rats

Aqueous extract

6 hrs

100 mg/kg = 33.7

200 mg/kg = 52.5

400 mg/kg = 65.5

100 mg/kg = − 35.8

200 mg/kg = − 17

400 mg/kg = − 4.2

Methanol extract

6 hrs

100 mg/kg = 34.8

200 mg/kg = 55.3

400 mg/kg = 67

100 mg/kg = − 34.7

200 mg/kg = − 14.2

400 mg/kg = − 2.5

Ethanol ulcer induced

Aqueous extract

5 days

200 mg/kg = 72.3

200 mg/kg = − 1

Methanol extract

5 days

200 mg/kg = 72.8

200 mg/kg = − 0.5

Indomethacin ulcer induced

Aqueous extract

5 days

200 mg/kg = 73.21

200 mg/kg = − 2.29

Methanol

5 days

200 mg/kg = 74.4

200 mg/kg = − 1.2