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International Journal of Phytomedicine and Phytotherapy

Fig. 1 | Clinical Phytoscience

Fig. 1

From: Hepatoprotective effect of oral application of a silymarin extract in carbon tetrachloride-induced hepatotoxicity in rats

Fig. 1

Effect of silymarin (SE) on hepatocellular damage in CCl4- induced liver injury. Rats were treated with MHPC (control) or silymarin (SE) at a single dose of 20 mg/kg BW (SE-20) or 100 mg/kg BW (SE-100) by oral gavage. After 3 h rats were injected with a single dose of CCl4 or the equal volume of vehicle (control). 24h after CCl4 injection, rats were sacrificed. a Liver-to-body -weight-ratio. b Representative macroscopic images of livers from the four treatment groups. c H&E staining of liver tissue (Magnification 20x) (left panel); quantification of ballooning hepatocytes in hepatic tissues (right panel). d Representative images of Ki67 stained liver tissues (left panel); quantification of Ki67 positive hepatocytes in hepatic tissues (right panel). e AST and ALT serum levels. (*: p < 0.05)

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