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International Journal of Phytomedicine and Phytotherapy

Fig. 2 | Clinical Phytoscience

Fig. 2

From: Hepatoprotective effect of oral application of a silymarin extract in carbon tetrachloride-induced hepatotoxicity in rats

Fig. 2

Effect of silymarin (SE) on the pro-inflammatory and pro-fibrogenic response in CCl4- induced liver injury. Rats were treated with MHPC (control) or silymarin (SE) at a single dose of 20 mg/kg BW (SE-20) or 100 mg/kg BW (SE-100) by oral gavage. After 3 h rats were injected with a single dose of CCl4 or the equivalent volume of vehicle (control). 24h after CCl4 injection, rats were sacrificed. Analysis of hepatic mRNA levels of (a) HMOX-1 (b) TNF (c) IL1-ß (d) MCP-1 and (e) TGFß1 by quantitative RT-PCR. f Analysis of the hepatic collagen content. g Analysis of hepatic mRNA levels of CYP2E1 by quantitative RT-PCR. (*: p < 0.05)

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