International Journal of Phytomedicine and Phytotherapy
Table 3 Short description of clinical studies with Cimiciduga racemosa preparations
From: Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy
Ref. (placebo or comparator controlled) | Design | Patient characteristics and age | Treatment, dose, and duration | Outcome measures | Finding and comments | Effects in short |
|---|---|---|---|---|---|---|
No = Ø | ||||||
Signif. pos = + | ||||||
Signif. neg = − | ||||||
Rostock et al., 2001 [30] | Prospective observational trial. This non placbo controlled study was incorporated because of the importance of its outcome | 50 breast cancer patients under tamoxifene | 1 to 4 times 2.5 mg of an isopropanolic extract daily for 6 months | Menopause Rating Scale II | Hot flushes, sweating, sleep problems and anxiety improved significantly | + |
Ross 2012 [48] | Randomized, double-blind, placebo-controlled | 304 post-meno- pausal women | Isopropanolic CR extract (40 mg dried rhizome powder daily (equivalent to 5 mg dried extract)), duration 12 weeks | Number of hot flushes | Significantly better improvement of severety and number of hot flushes | + |
Schellenberg et al. 2012 [49] | Randomized, comparator controlled trial | 180 women with climacteric complaints | 6.5 or 13 mg of the CR extract Ze 450 vs placebo, duration 12 weeks | Kuppermans’s Menopausal Index. | Significant dose dependent improvement under CR | + |
Mohammad-Alizadeh-Charandabi et al. 2013 [50] | Randomized, double-blind, placebo-controlled trial | 84 early postmeno-pausal women | 6.5 mg of a dried CR extracr vs placebo, duration 8 weeks | Greene Climacteric Scale | Significant more improvement by the CR extract of all GCS scores (vasomotor, psychiatric, physical and sexual symptoms) | + |
Pokul and Porkhanova 2007 [55]- ----------------Stefanovskaya et al. 2011 [56] | Prospective comparator controlled trial | 226 oopher-ectomized women with estrogen dependant cancer | Aquous-ethanolic CR extract BNO 1055 (40 mg dried rhizome powder daily (equivalent to approximately 6.5 mg dried extract)) vs vitamins | Climacteric complaint questionnaire, Hamilton depression scale, sonography of mammary gland, urinary bladder tonus | Under BNO1055 significant improvement of psychosomatic complaints and increased bladder tonus. No change in mammary gland | + |
Comparator controlled study was incorporated because of the importance of its outcome | 36 post-menopausal women with metabolic syndrome | Aquous-ethanolic 6.5 mg CR extract BNO 1055 6.5 mg vs vitamins for 6 months | Menopausal index, abdominal obesity, lipids | Reduction of psychsomatic complaints and of cholesterol, LDL, triglycerides and fasting glucose. . Increased HDL | + |