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International Journal of Phytomedicine and Phytotherapy

Table 3 Short description of clinical studies with Cimiciduga racemosa preparations

From: Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

Ref. (placebo or comparator controlled) Design Patient characteristics and age Treatment, dose, and duration Outcome measures Finding and comments Effects in short
No = Ø
Signif. pos = +
Signif. neg = −
Rostock et al., 2001 [30] Prospective observational trial. This non placbo controlled study was incorporated because of the importance of its outcome 50 breast cancer patients under tamoxifene 1 to 4 times 2.5 mg of an isopropanolic extract daily for 6 months Menopause Rating Scale II Hot flushes, sweating, sleep problems and anxiety improved significantly +
Ross 2012 [48] Randomized, double-blind, placebo-controlled 304 post-meno- pausal women Isopropanolic CR extract (40 mg dried rhizome powder daily (equivalent to 5 mg dried extract)), duration 12 weeks Number of hot flushes Significantly better improvement of severety and number of hot flushes +
Schellenberg et al. 2012 [49] Randomized, comparator controlled trial 180 women with climacteric complaints 6.5 or 13 mg of the CR extract Ze 450 vs placebo, duration 12 weeks Kuppermans’s Menopausal Index. Significant dose dependent improvement under CR +
Mohammad-Alizadeh-Charandabi et al. 2013 [50] Randomized, double-blind, placebo-controlled trial 84 early postmeno-pausal women 6.5 mg of a dried CR extracr vs placebo, duration 8 weeks Greene Climacteric Scale Significant more improvement by the CR extract of all GCS scores (vasomotor, psychiatric, physical and sexual symptoms) +
Pokul and Porkhanova 2007 [55]-
----------------Stefanovskaya et al. 2011 [56]
Prospective comparator controlled trial 226 oopher-ectomized women with estrogen dependant cancer Aquous-ethanolic CR extract BNO 1055 (40 mg dried rhizome powder daily (equivalent to approximately 6.5 mg dried extract)) vs vitamins Climacteric complaint questionnaire, Hamilton depression scale, sonography of mammary gland, urinary bladder tonus Under BNO1055 significant improvement of psychosomatic complaints and increased bladder tonus. No change in mammary gland +
Comparator controlled study was incorporated because of the importance of its outcome 36 post-menopausal women with metabolic syndrome Aquous-ethanolic 6.5 mg CR extract BNO 1055 6.5 mg vs vitamins for 6 months Menopausal index, abdominal obesity, lipids Reduction of psychsomatic complaints and of cholesterol, LDL, triglycerides and fasting glucose. . Increased HDL +
  1. CE conjugated oestrogens, CR Cimicifuga racemosa, DB double blind, GCS greene climacteric scale, KMI Kupperman menopause index, MRS menopause rating scale, PM postmenopausal, RCT randomised controlled trial