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International Journal of Phytomedicine and Phytotherapy

Table 3 Short description of clinical studies with Cimiciduga racemosa preparations

From: Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

Ref. (placebo or comparator controlled)


Patient characteristics and age

Treatment, dose, and duration

Outcome measures

Finding and comments

Effects in short

No = Ø

Signif. pos = +

Signif. neg = −

Rostock et al., 2001 [30]

Prospective observational trial. This non placbo controlled study was incorporated because of the importance of its outcome

50 breast cancer patients under tamoxifene

1 to 4 times 2.5 mg of an isopropanolic extract daily for 6 months

Menopause Rating Scale II

Hot flushes, sweating, sleep problems and anxiety improved significantly


Ross 2012 [48]

Randomized, double-blind, placebo-controlled

304 post-meno- pausal women

Isopropanolic CR extract (40 mg dried rhizome powder daily (equivalent to 5 mg dried extract)), duration 12 weeks

Number of hot flushes

Significantly better improvement of severety and number of hot flushes


Schellenberg et al. 2012 [49]

Randomized, comparator controlled trial

180 women with climacteric complaints

6.5 or 13 mg of the CR extract Ze 450 vs placebo, duration 12 weeks

Kuppermans’s Menopausal Index.

Significant dose dependent improvement under CR


Mohammad-Alizadeh-Charandabi et al. 2013 [50]

Randomized, double-blind, placebo-controlled trial

84 early postmeno-pausal women

6.5 mg of a dried CR extracr vs placebo, duration 8 weeks

Greene Climacteric Scale

Significant more improvement by the CR extract of all GCS scores (vasomotor, psychiatric, physical and sexual symptoms)


Pokul and Porkhanova 2007 [55]-

----------------Stefanovskaya et al. 2011 [56]

Prospective comparator controlled trial

226 oopher-ectomized women with estrogen dependant cancer

Aquous-ethanolic CR extract BNO 1055 (40 mg dried rhizome powder daily (equivalent to approximately 6.5 mg dried extract)) vs vitamins

Climacteric complaint questionnaire, Hamilton depression scale, sonography of mammary gland, urinary bladder tonus

Under BNO1055 significant improvement of psychosomatic complaints and increased bladder tonus. No change in mammary gland


Comparator controlled study was incorporated because of the importance of its outcome

36 post-menopausal women with metabolic syndrome

Aquous-ethanolic 6.5 mg CR extract BNO 1055 6.5 mg vs vitamins for 6 months

Menopausal index, abdominal obesity, lipids

Reduction of psychsomatic complaints and of cholesterol, LDL, triglycerides and fasting glucose. . Increased HDL


  1. CE conjugated oestrogens, CR Cimicifuga racemosa, DB double blind, GCS greene climacteric scale, KMI Kupperman menopause index, MRS menopause rating scale, PM postmenopausal, RCT randomised controlled trial