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International Journal of Phytomedicine and Phytotherapy

Clinical Phytoscience Cover Image

Table 5 Most common AE in the study by Osmers et al. (2005) [41] by system organ class (MedDRA)

From: Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

System organ class Remifemin 40 mg Placebo Total
N = 153 N = 151 N = 304
  N N N (%)
Infections and infestations 13 19 32 (10.5)
Musculoskeletal and connective tissue disorders 15 10 25 (8.2)
Gastrointestinal disorders 8 7 15 (4.9)
Investigations 6 5 11 (0.4)
Nervous system disorders 4 5 9 (3.0)
Reproductive system and breast disorders 4 4 8 (2.6)
Psychiatric disorders 2 5 7 (2.3)
Skin and subcutaneous disorders 3 3 6 (2.0)
Blood and lymphatic disorders 1 1 2 (0.7)
Cardiac disorders 2   2 (0.7)
General disorders and administration site conditions 1 1 2 (0.7)
Vascular disorders 1 1 2 (0.7)
Injury poisoning and procedural complications 2   2 (0.7)
Metabolism and nutrition disorders 2   2 (0.7)
Ear and labyrinth disorders   1 1 (0.3)
Renal and urinary disorders 1   1 (0.3)
Respiratory, thoracic and mediastinal disorders   1 1 (0.3)