A preliminary evaluation of cytotoxicity, antihyperglycemic and antinociceptive activity of Polygonum hydropiper L. ethanolic leaf extract

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Antinociceptive effect of crude ethanolic leaf extract of P. hydropipper L. in acetic acid-induced pain model mice. All administrations (aspirin and extract) were made orally

Treatment	Dose (mg/kg body weight)	Mean number of abdominal writhings	% inhibition
Control	10 ml	15.6 ± 0.75	--
Aspirin	200 mg	9.2 ± 0.66	41.02*
Aspirin	400 mg	4.8 ± 0.37	69.23*
EEPHL	50 mg	13.4 ± 0.51	14.10*
EEPHL	100 mg	12.8 ± 0.37	17.95*
EEPHL	200 mg	11 ± 0.71	29.49*
EEPHL	400 mg	9.2 ± 0.75	41.02*

Values represented as mean ± SEM, (n = 5); *P < 0.05; significant compared to control