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International Journal of Phytomedicine and Phytotherapy

Table 1 Summary of pharmacokinetic parameters of silymarin in the human body [2931]

From: The potential of silymarin for the treatment of hepatic disorders

Tmax Plasmatic half life (non-conjugated) Cmax (oral dose of 600 mg) Metabolism Excretion
1.0–3.7 h 1–3,2 h 53.1 ng/ml (free flavonolignans)
84.3 ng/ml (sulphated silymarin)
168 ng/ml (glucoronidated silymarin)
Phase II metabolites
sulphates, glucorinide, diglucorinides
via bile and urine
(conjugated)
3.3–7.9 h