International Journal of Phytomedicine and Phytotherapy
Table 1 Summary of pharmacokinetic parameters of silymarin in the human body [29–31]
From: The potential of silymarin for the treatment of hepatic disorders
Tmax | Plasmatic half life (non-conjugated) | Cmax (oral dose of 600Â mg) | Metabolism | Excretion |
|---|---|---|---|---|
1.0–3.7 h | 1–3,2 h | 53.1 ng/ml (free flavonolignans) 84.3 ng/ml (sulphated silymarin) 168 ng/ml (glucoronidated silymarin) | Phase II metabolites sulphates, glucorinide, diglucorinides | via bile and urine |
(conjugated) | ||||
3.3–7.9 h |