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International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of therapy with prednisolone, CAN and their combination on the main immunological markers of autoimmune renal pathology (mean ± SEM, n = 8 in each group)

From: Efficiency of Canephron N in complex treatment of experimental heymann glomerulonephritis

Groups of animals Study parameters
CD3+, ×109/L CD4 + CD3+, % CD8 + CD3+, % Immune-regulatory index (CD4+/CD8+)
Healthy 5,7 ± 0,1 55,2 ± 0,9 44,1 ± 1,1 1,26 ± 0,04
AIG 5,5 ± 0,1 51,0 ± 1,6* 25,6 ± 1,3* 2,01 ± 0,07*
AIG + Prednisolone 4,9 ± 0,1 */† 52,1 ± 1,1 30,2 ± 1,3*/† 1,74 ± 0,07*/†
AIG + CAN 5,6 ± 0,1# 51,9 ± 1,2 26,2 ± 1,4* 2,00 ± 0,09*
AIG + Prednisolone + CAN 5,1 ± 0,1*/† 54,2 ± 0,7 34,5 ± 0,6*/†/# 1,58 ± 0,04*/†
  1. * -differences are significant vs. healthy rats, р ≤ 0,05
  2. † −differences are significant vs. AIG group, р ≤ 0,05
  3. # -differences are significant vs. Prednisolone group, p ≤ 0,05