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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of therapy with prednisolone, CAN and their combination on renal function in autoimmune glomerulonephritis (mean ± SEM, n = 8 in each group)

From: Efficiency of Canephron N in complex treatment of experimental heymann glomerulonephritis

Groups of animals Study parameters
Diuresis, mL/day GFR, mL/min Protein, g/mmol Cr Erythrocytes, ×103/mL Leukocytes, ×103/mL Casts, units/mL
Healthy 13,3 ± 0,6 4,50 ± 0,32 0,13 ± 0,01 1,87 ± 0,69 7,6 ± 1,3 10,0 ± 4,2
AIG 5,6 ± 0,5* 0,63 ± 0,13* 1,05 ± 0,14* 27,25 ± 5,47* 324,4 ± 50,6* 102,5 ± 25,9 *
AIG + Prednisolone 10,5 ± 0,9*/† 2,98 ± 0,45*/† 0,43 ± 0,03*/† 9,25 ± 1,25*/† 197,0 ± 29,.2*/† 23,6 ± 3,2†
AIG + CAN 9,7 ± 0,9*/† 1,37 ± 0,14*/†/# 0,70 ± 0,05*/# 15,12 ± 0,79*/# 149,5 ± 46,6*/† 48,2 ± 5,3*/#
AIG + Prednisolone + CAN 12,5 ± 1,1† 3,24 ± 0,23*/† 0,29 ± 0,05*/† 5,00 ± 0,75*/†/# 82,6 ± 7,7*/†/# 19,0 ± 3,8†
  1. * -differences are significant vs. healthy rats, р ≤ 0,05
  2. † −differences are significant vs. AIG group, р ≤ 0,05
  3. # -differences are significant vs. Prednisolone group, p ≤ 0,05