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International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of aqueous leaf extract of C. afer on BUN, serum creatinine and electrolyte in experimental groups

From: Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Treatments

Na (nmol/l)

K(nmol/l)

Cr (μmol/l)

BUN (mmol/l)

HCO3 (mmol/l)

NC

102.00±27.62bc

7.10 ± 0.10

457.00±73.19

1.40 ± .60b

27.33 ± 1.16

TC (CsA(50 mg/kg)

36.00± 4.00a

9.20± 1.15

481.33±116.43

4.70±0.98ac

24.67 ± 1.16

CsA+ 375 mg/kg extract

57.00± 7.55a

6.20 ±0.90b

463.33±41.79

2.13±0.12b

27.33 ± 1.16

CsA+ 750 mg/kg Extract

57.00 ± 7.55a

7.30± 1.25

414.67±64.39

1.63±0.55b

26.00 ± 2.00

CsA+ 1125 mg/kg Extract

58.00 ± 15.62a

5.70± 0.17b

381.33±63.50

2.87±0.70b

24.67 ± 1.16

CsA+ Silymarin (100 mg/kg)

75.33 ± 75.33b

7.47 ± .25

427.33±83.36

2.13± 0.70b

24.00 ± 2.00

  1. All values represent Mean ± SD (n=5); a = p<0.05 vs Control; b = p<0.05 vs CsA alone; c=p<0.05 vs Silymarin. Cr (creatinine), Ur(blood urea nitrogen)