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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effects of the medicinal plants on liver enzymes in acetaminophen-induced hepatotoxic rats

From: An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Experimental groups

ALT (U/L)

AST (U/L)

ALP (U/L)

LDH (U/L)

Healthy Control

87 ± 12*

97 ± 9*

340 ± 37*

474 ± 29*

Healthy Control + silymarin

70 ± 8*

99 ± 13*

440 ± 45*

321 ± 27*

AIHa Control

480 ± 31

385 ± 32

745 ± 43

890 ± 47

AIH + B. vulgaris (100 mg/kg)

340 ± 21

170 ± 12*

370 ± 36*

560 ± 41*

AIH + B. vulgaris (200 mg/kg)

290 ± 14*

158 ± 11*

340 ± 32*

315 ± 19*

AIH + Z. Jujuba(100 mg/kg)

222 ± 18*

110 ± 10*

430 ± 27*

237 ± 21*

AIH + Z. Jujuba(200 mg/kg)

208 ± 21*

95 ± 12*

314 ± 39*

230 ± 24*

AIH + C. sativus (petal) (100 mg/kg)

225 ± 17*

162 ± 22*

416 ± 36*

710 ± 42*

AIH + C. sativus (petal) (200 mg/kg)

138 ± 9*

144 ± 11*

364 ± 16*

615 ± 34*

AIH + C. sativus (stigma) (40 mg/kg)

260 ± 13*

177 ± 18*

412 ± 28*

640 ± 31*

AIH + C. sativus (stigma) (80 mg/kg)

240 ± 19*

140 ± 15*

390 ± 29*

525 ± 35*

AIH + Silymarin

117 ± 12*

110 ± 17*

310 ± 21*

520 ± 37*

AIH + Mix (PS)b

119 ± 11*

105 ± 8*

320 ± 29*

510 ± 43*

AIH + Mix (ZB)b

107 ± 16*

75 ± 9*

310 ± 16*

350 ± 24*

  1. In each column, *was considered significant at P < 0.05 when compared with the AIH group
  2. aAIH: acetaminophen-induced hepatotoxic group
  3. bZB: mixture of Z.jujuba and B.vulgaris in low dose, PS: mixture of C.sativus petals and stigma in low dose
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