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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of the medicinal plants on liver enzymes in rifampicin-induced hepatotoxic rats

From: An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Experimental groups ALT (U/L) AST (U/L) ALP (U/L) LDH (U/L)
Healthy Control 87 ± 12* 97 ± 9 340 ± 37 474 ± 29*
Healthy Control + silymarin 70 ± 8 99 ± 13* 440 ± 45* 321 ± 27*
RIHa Control 410 ± 31* 370 ± 32 720 ± 43 923 ± 47
RIH + B. vulgaris (100 mg/kg) 270 ± 17* 278 ± 21 440 ± 35* 610 ± 42*
RIH + B. vulgaris (200 mg/kg) 243 ± 9* 186 ± 13* 385 ± 29* 435 ± 27*
RIH + Z. Jujuba (100 mg/kg) 215 ± 18* 145 ± 16* 415 ± 29* 225 ± 21*
RIH + Z. Jujuba (200 mg/kg) 165 ± 17* 110 ± 12* 335 ± 31* 210 ± 22*
RIH + C. sativus (petal) (100 mg/kg) 220 ± 9* 201 ± 14* 420 ± 29* 690 ± 38*
RIH + C. sativus (petal) (200 mg/kg) 152 ± 7* 150 ± 13* 350 ± 25* 605 ± 28*
RIH + C. sativus (stigma) (40 mg/kg) 246 ± 14* 202 ± 21* 390 ± 33* 585 ± 39*
RIH + C. sativus (stigma) (80 mg/kg) 170 ± 11* 160 ± 9* 362 ± 24* 460 ± 34*
RIH + Silymarin 124 ± 10* 113 ± 15* 298 ± 23* 340 ± 27*
RIH + Mix (PS)b 121 ± 7* 125 ± 16* 315 ± 26* 295 ± 19*
RIH + Mix (ZB)b 109 ± 12* 94 ± 8* 295 ± 13* 310 ± 21*
  1. In each column, *was considered significant at P < 0.05 when compared with the RIH group
  2. aRIH: rifampicin-induced hepatotoxic group
  3. bZB: mixture of Z.jujuba and B.vulgaris in low dose, PS: mixture of C.sativus petals and stigma in low dose