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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of the medicinal plants on liver enzymes in rifampicin-induced hepatotoxic rats

From: An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Experimental groups

ALT (U/L)

AST (U/L)

ALP (U/L)

LDH (U/L)

Healthy Control

87 ± 12*

97 ± 9

340 ± 37

474 ± 29*

Healthy Control + silymarin

70 ± 8

99 ± 13*

440 ± 45*

321 ± 27*

RIHa Control

410 ± 31*

370 ± 32

720 ± 43

923 ± 47

RIH + B. vulgaris (100 mg/kg)

270 ± 17*

278 ± 21

440 ± 35*

610 ± 42*

RIH + B. vulgaris (200 mg/kg)

243 ± 9*

186 ± 13*

385 ± 29*

435 ± 27*

RIH + Z. Jujuba (100 mg/kg)

215 ± 18*

145 ± 16*

415 ± 29*

225 ± 21*

RIH + Z. Jujuba (200 mg/kg)

165 ± 17*

110 ± 12*

335 ± 31*

210 ± 22*

RIH + C. sativus (petal) (100 mg/kg)

220 ± 9*

201 ± 14*

420 ± 29*

690 ± 38*

RIH + C. sativus (petal) (200 mg/kg)

152 ± 7*

150 ± 13*

350 ± 25*

605 ± 28*

RIH + C. sativus (stigma) (40 mg/kg)

246 ± 14*

202 ± 21*

390 ± 33*

585 ± 39*

RIH + C. sativus (stigma) (80 mg/kg)

170 ± 11*

160 ± 9*

362 ± 24*

460 ± 34*

RIH + Silymarin

124 ± 10*

113 ± 15*

298 ± 23*

340 ± 27*

RIH + Mix (PS)b

121 ± 7*

125 ± 16*

315 ± 26*

295 ± 19*

RIH + Mix (ZB)b

109 ± 12*

94 ± 8*

295 ± 13*

310 ± 21*

  1. In each column, *was considered significant at P < 0.05 when compared with the RIH group
  2. aRIH: rifampicin-induced hepatotoxic group
  3. bZB: mixture of Z.jujuba and B.vulgaris in low dose, PS: mixture of C.sativus petals and stigma in low dose
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