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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effects of the medicinal plants on total antioxidant capacity and lipid peroxidation in rifampicin-induced hepatotoxicity in rats

From: An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Experimental groups

Total Antioxidant Capacity (TAC) (μmol/l)

Malondialdehyde (MDA) (μmol/l)

Healthy Control

760 ± 21*

1.9 ± 0.53*

Healthy Control + silymarin

756 ± 14*

2.1 ± 0.32*

RIHa Control

460 ± 16

5.9 ± 0.64

RIH + B. vulgaris (100 mg/kg)

518 ± 21

4.6 ± 0.15

RIH + B. vulgaris (200 mg/kg)

554 ± 18*

3.4 ± 0.11

RIH + Z. jujuba (100 mg/kg)

540 ± 12

3.1 ± 0.19

RIH + Z. jujuba (200 mg/kg)

635 ± 14*

2.4 ± 0.17*

RIH + C. sativus (petal) (100 mg/kg)

589 ± 12*

3.1 ± 0.22

RIH + C. sativus (petal) (200 mg/kg)

632 ± 21*

2.3 ± 0.12*

RIH + C. sativus (stigma) (40 mg/kg)

610 ± 17*

2.9 ± 0.19

RIH + C. sativus (stigma) (80 mg/kg)

652 ± 25*

2.1 ± 0.32*

RIH + Silymarin

710 ± 23*

1.9 ± 0.25*

RIH + Mix (PS)b

675 ± 24*

2 ± 0.14*

RIH + Mix (ZB)b

690 ± 19*

1.9 ± 0.18*

  1. In each column, *was considered significant at P < 0.05 when compared with the RIH group
  2. aRIH: rifampicin-induced hepatotoxic group
  3. bZB: mixture of Z.jujuba and B.vulgaris in low dose, PS: mixture of C.sativus petals and stigma in low dose
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