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International Journal of Phytomedicine and Phytotherapy

Table 4 Effects of the medicinal plants on total antioxidant capacity and lipid peroxidation in rifampicin-induced hepatotoxicity in rats

From: An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Experimental groups Total Antioxidant Capacity (TAC) (μmol/l) Malondialdehyde (MDA) (μmol/l)
Healthy Control 760 ± 21* 1.9 ± 0.53*
Healthy Control + silymarin 756 ± 14* 2.1 ± 0.32*
RIHa Control 460 ± 16 5.9 ± 0.64
RIH + B. vulgaris (100 mg/kg) 518 ± 21 4.6 ± 0.15
RIH + B. vulgaris (200 mg/kg) 554 ± 18* 3.4 ± 0.11
RIH + Z. jujuba (100 mg/kg) 540 ± 12 3.1 ± 0.19
RIH + Z. jujuba (200 mg/kg) 635 ± 14* 2.4 ± 0.17*
RIH + C. sativus (petal) (100 mg/kg) 589 ± 12* 3.1 ± 0.22
RIH + C. sativus (petal) (200 mg/kg) 632 ± 21* 2.3 ± 0.12*
RIH + C. sativus (stigma) (40 mg/kg) 610 ± 17* 2.9 ± 0.19
RIH + C. sativus (stigma) (80 mg/kg) 652 ± 25* 2.1 ± 0.32*
RIH + Silymarin 710 ± 23* 1.9 ± 0.25*
RIH + Mix (PS)b 675 ± 24* 2 ± 0.14*
RIH + Mix (ZB)b 690 ± 19* 1.9 ± 0.18*
  1. In each column, *was considered significant at P < 0.05 when compared with the RIH group
  2. aRIH: rifampicin-induced hepatotoxic group
  3. bZB: mixture of Z.jujuba and B.vulgaris in low dose, PS: mixture of C.sativus petals and stigma in low dose