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International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of S. alata leaf extract on metabolic parameters in HFD-induced obese mice

From: Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice

Groups NC OB OB + S. alata (mg/kg)
250 500
Body weight (g) 44.0 ± 0.70 50.0 ± 1.68 * 48.6 ± 1.20 * 48.7 ± 1.13 *
FBG (mM) 5.5 ± 0.14 9.9 ± 0.61* 7.5 ± 0.28 *, ** 7.4 ± 0.16 *, **
Insulin (ng/mL) 0.6 ± 0.06 3.6 ± 0.23 * 2.4 ± 0.26 *, ** 2.3 ± 0.25 *, **
HOMA-IR 3.8 ± 0.41 37.7 ± 3.08 * 19.2 ± 1.84 *, ** 18.7 ± 2.96 *, **
Leptin (ng/mL) 1.3 ± 0.28 15.0 ± 1.15 * 10.3 ± 0.72 *, ** 10.0 ± 0.72 *, **
Adiponectin (pg/mL) 7.6 ± 0.25 5.9 ± 0.44 * 9.1 ± 0.31 *, ** 9.6 ± 0.26 *, **
MCP-1 (pg/mL) 3.9 ± 0.46 16.2 ± 1.10 * 5.0 ± 0.67 * 3.9 ± 0.50 *
TNF-α (pg/mL) 5.1 ± 0.70 18.5 ± 1.52 * 10.6 ± 0.72 *, ** 8.7 ± 0.61 *, **
  1. Values are represented as mean ± SEM (n = 8). * P < 0.05 compared to normal control group
  2. ** P < 0.05 compared to obese control group. NC normal control mice fed with LFD, OB obese mice fed with HFD, FBG fasting blood glucose, MCP-1 monocyte chemoattractant protein-1, TNF-α tumor necrosis factor-α