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International Journal of Phytomedicine and Phytotherapy

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Table 4 Antioxidants activities of Central African plants

From: African natural products with potential antioxidants and hepatoprotectives properties: a review

Plants Family Part used Solvents Assay Methods Inhibition/IC50 Country of origin References
Abrus precatorius L Papiliomoidae Leaf MeOH DPPH 6.88% Cameroon [53]
Acalypha manniana Mull. Arg. Euphobiaceae Leaf MeOH/n-C6H12 DPPH 4.51 and 4.80% Cameroon [264]
Acalypha racemosa B. Heyne. Euphorbiaceae Leaf/Stem MeOH DPPH/NO/HO 2.11,1.92,2.12/2.28.1.49,10.04 μg/mL Cameroon [52]
Acanthus montanus T. Anderson Acanthaceae Leaf MeOH DPPH 9.88% Cameroon [53]
Adenocarpus mannii Hook. f Fabaceae Leaf EtOH DPPH 361.30 μg/mL Cameroon [265]
Ageratum conizoides L. Asteraceae Leaf MeOH DPPH 9.05% Cameroon [53]
Ageratum conyzoides L. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −9.31% at 200 μg/mL Cameroon [117]
Alchornea cordifolia Pax & K. Hoffm. Euphorbiaceae Leaf MeOH DPPH 39.70% Cameroon [53]
Alchornea laxiflora Pax & K. Hoffm. Euphorbiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 95.90% at 200 μg/mL Cameroon [117]
Allanblackia floribunda L. Guttiferae Root Bark MeOH DPPH 76.3 μg/mL Cameroon [266]
Amaranthus spinosa L. Amaranthaceae Leaf MeOH DPPH 3.78% Cameroon [53]
Annona muricata L. Annonaceae Leaf MeOH DPPH 9.88% Cameroon [53]
Annona senegalensis Pers. Anonaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 16.17% at 200 μg/mL Cameroon [117]
Anthocleista schweinfurthii Gilg. Gentianaceae Leaf MeOH DPPH 1.20 μg/mL Congo [267]
Anthocleista schweinfurthii Gilg. Loganiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −0.05% at 200 μg/mL Cameroon [117]
Aspilia africana Pers. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 52.91% at 200 μg/mL Cameroon [117]
Asystasia gangetica A. Juss. Acanthaceae Leaf MeOH DPPH 3.08% Cameroon [53]
Azadirachta indica A. Juss. Meliaceae Bark/Leaf MeOH DPPH 59.80/2.88% Cameroon [53]
Barteria fistulosa Mast. Passifloraceae Leaf EtOH DPPH 100.16 μg/mL Cameroon [265]
Bersama engleriana Gunke. Melianthaceae Leaf MeOH DPPH 93.71% at 1000 μg/mL Cameroon [268]
Bidens pilosa L. Asteraceae Leaf MeOH DPPH 7.57% Cameroon [53]
Bidens pilosa L. Asteraceae Bark/leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 50.92% at 200 μg/mL Cameroon [117]
Bracica dera L. Bracicaceae Leaf MeOH DPPH 5.11% Cameroon [53]
Carica papaya L. Caricaceae Leaf MeOH DPPH 7.72% Cameroon [53]
Carica papaya L. Caricaceae Bark/leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −2.68% at 200 μg/mL Cameroon [117]
Cassia alata L. Legceasalpoidee Leaf MeOH DPPH 1.95% Cameroon [53]
Ceiba pentandra L. Bombacea Bark MeOH DPPH 28.72% Cameroon [53]
Centella asiatica Urb. Apiaceae Whole plant MeOH DPPH/NO - Cameroon [269]
Centella asiatica Urb. Apiaceae Whole plant MeOH DPPH/NOSA - Cameroon [269]
Chrysanthellum americanum Vatke. Asteraceae Bark/leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 17.20% at 200 μg/mL Cameroon [117]
Cissus populnea Guill & Perr. Vitaceae Root MeOH DPPH/NO 15.72/409 μg/mL Cameroon [269]
Cissus populnea Guill & Perr. Vitaceae Root MeOH DPPH/NOSA 15.72/409.00 μg/mL Cameroon [269]
Cissus quadrangularis L. Vitaceae Leaf MeOH DPPH 2.60% Cameroon [53]
Citrus aurantifolia (Christm.) Swingle. Rutaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 54.59% at 200 μg/mL Cameroon [117]
Citrus sinensis Pers. Rutaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 100.00% at 200 μg/mL Cameroon [117]
Cleome ciliatea Cleomaceae Leaf MeOH DPPH 1.95% Cameroon [53]
Clerodendrum formicarum Gurke. Lamiacea Leaf MeOH DPPH >200 μg/mL Cameroon [140]
Coffea arabica L. Rubiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 10.05% at 200 μg/mL Cameroon [117]
Coffea robusta L. Linden Rubiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 41.23% at 200 μg/mL Cameroon [117]
Coleus coprosijblius Lamiaceae Leaf MeOH DPPH 39.58% Cameroon [53]
Cordyline fruticosa (L.) A. Chev. Agavaceae Leaf MeOH DPPH 181.30 μg/mL Cameroon [270]
Costus afer L. Costaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 68.16% at 200 μg/mL Cameroon [117]
Costus afer L. Costaceae Leaf MeOH DPPH 3.04% Cameroon [53]
Crinum sp. Amarillidaceae Leaf MeOH DPPH 4.69% Cameroon [53]
Crotalaria lachnophora Hochst. ex. R. Fabaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 97.41% at 200 μg/mL Cameroon [117]
Curcuma longa L. Zingiberaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 90.36% at 200 μg/mL Cameroon [117]
Cylicodiscusgabunensis Harms. Mimosaceae Bark MeOH DPPH 28.00% Cameroon [53]
Cymbopogon citrates Stapf. Poaceae Leaf BtOH DPPH/FRAP/RP/H2O2/NO - Angola [271]
Cymbopogon citrates Stapf. Poaceae Leaf MeOH DPPH 6.05% Cameroon [53]
Cymbopogon citrates Stapf. Poaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −9.66% at 200 μg/mL Cameroon [117]
Dacryodes edulis (G.Don) H.J. Lam. Burseraceae Leaf MeOH DPPH 93.01% Cameroon [53]
Dacryodes edulis (G.Don) H.J. Lam. Burseraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −8.20% at 200 μg/mL Cameroon [117]
Dichrocephala integrifolia (L.F) Knntze. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 25.43% at 200 μg/mL Cameroon [117]
Dichrostachys glomerata Chi. Mimosaceae Seed EtOAc/MeOH DPPH High Cameroon [272]
Dissotis perkinsiae Gilg. Melastomaceae Leaf EtOH DPPH 130.66 μg/mL Cameroon [265]
Dorstenia barteri Bureau. Moraceae Leaf/Twig EtOAc/MeOH DPPH 60.46/48.12 μg/mL Cameroon [31]
Dracaena deisteliana Engl. Dracaenaceae Leaf MeOH DPPH 6.66% Cameroon [53]
Draceana deisteliana Engl. Agavaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −0.46% at 200 μg/mL Cameroon [117]
Ekebergia senegalensis Fuss. Meliaceae Back MeOH DPPH 15.83 μg/mL Cameroon [269]
Ekebergia senegalensis Fuss. Meliaceae Bark MeOH DPPH/NOSA 15.83/299 μg/mL Cameroon [269]
Eleusine indica Gaertn. Poaceae Leaf MeOH DPPH 1.36% Cameroon [53]
Emilia coccinia Cass. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −1.51% at 200 μg/mL Cameroon [117]
Emilia cocinea Cass. Asteraceae Leaf MeOH DPPH 2.99% Cameroon [53]
Enantia chlorantha Oliv. Anonaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 53.97% at 200 μg/mL Cameroon [117]
Entada africana Guill & perr. Mimosaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 82.73% at 200 μg/mL Cameroon [117]
Entandophragma angolense L. Meliaceae Bark MeOH DPPH 7.60 Cameroon [53]
Eremomastas speciosa (Hochst.) Cufod. Acanthaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 46.16% at 200 μg/mL Cameroon [117]
Eremomastas speciosa (Hochst.) Cufod. Acanthaceae Leaf MeOH DPPH/NO 454/278 μg/mL Cameroon [269]
Eremomastas speciosa (Hochst.) Cufod. Acanthaceae Leaf MeOH DPPH 454 μg/mL Cameroon [269]
Eremomastas speciosa (Hochst.) Cufod. Acanthaceae Leaf MeOH DPPH 5.43% Cameroon [53]
Eriobotrya japonica (Thunb) Lindl Rosaceae Stem bark MeOH DPPH 16.55 μg/mL Cameroon [270]
Erythrina Senegalensis L. Fabaceae Stem bark EtOH ß-CLAMS/FRAP/MLP 12.35/, 10.24/1.47 μg/mL Cameroon [273]
Erythrina Senegalensis L. Fabaceae Stem bark MeOH DPPH 46.9 μg/mL Cameroon [274]
Erythrina senegalensis L. Fabaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 94.25% at 200 μg/mL Cameroon [117]
Erythrina vogelii Hook. f. Fabaceae Leaf MeOH DPPH >200 μg/mL Cameroon [140]
Eucalyptus oblique L Her. Myrtaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 76.19% at 200 μg/mL Cameroon [117]
Faraga macrophylla Rutaceae Bark MeOH DPPH 2.29% Cameroon [53]
Ficus asperifolia Miq. Moraceae Stem bark MeOH DPPH Least activity Cameroon [272]
Ficus exasperata Vahl. Moraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −6.98% at 200 μg/mL Cameroon [117]
Ficus sur Forssk. Moraceae Leaf MeOH DPPH 4.91% Cameroon [53]
Garcinia lucida Vesque. Clusiaceae Fruit/Bark MeOH DPPH, NO, HO 1.83,3.12,1.99/2.35,3.59,2.01 μg/mL Cameroon [52]
Gardenia aqualla J.Ellis Rubiaceae Leaf MeOH DPPH/NO 105.9/253 μg/mL Cameroon [269]
Gardenia aqualla J.Ellis Rubiaceae Leaf MeOH DPPH/NOSA 105.90/278.00 μg/mL Cameroon [269]
Gladiolus dalenii L. Iridaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −8.23% at 200 μg/mL Cameroon [117]
Gosypium barbadense L. Malvaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 56.98% at 200 μg/mL Cameroon [117]
Harungana madagascariensis Lam. Hypercaceae Leaf MeOH DPPH 90.15% Cameroon [53]
Harungana madagascariensis Lam. Hypericaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 81.75% at 200 μg/mL Cameroon [117]
Hibiscus asper Hook. f. Malvaceae Aerial parts n-C6H12 DPPH Least activity Cameroon [272]
Hymenocardia lyrata Miq. Phllantaceae Root/bark MeOH DPPH/NO/HO 1.96,3.82,2.43/1.74,2.46,3.30 μg/mL Cameroon [52]
Ipomea batatas Blackie. Convolvulaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 14.30% at 200 μg/mL Cameroon [117]
Irvingia wombolu Hook. f. Irvingiaceae Pulp H2O DPPH/FRAP/ABTS. OH 37.86/15.55/55.53%31.63 at 1 mg/mL Cameroon [275]
Kalonchoe crenata (Andrews) Haw. Crasulaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 73.70% at 200 μg/mL Cameroon [117]
Khaya grandifoliola C. DC. Meliaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 78.91% at 200 μg/mL Cameroon [117]
Lannea kerstingii Engl. & K. Krause. Anacardiaceae Back MeOH DPPH/NO 34.40/306 μg/mL Cameroon [269]
Lannea kerstingii Engl. & K. Krause. Anacardiaceae Bark MeOH DPPH/NOSA 34.40/253.00 μg/mL Cameroon [269]
Lantana camara L. Verbenaceae Leaf MeOH DPPH 23.47% Cameroon [53]
Lippia adoensis L. Lamiaceae Leaf MeOH DPPH 10.41% Cameroon [53]
Lygopodium macrophyllum L. Pteridophyte Leaf MeOH DPPH 14.72% Cameroon [53]
Mangifera indica L. Anacardiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 75.35% at 200 μg/mL Cameroon [117]
Manihot esculenta Crantz. Euphorbiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −4.80% at 200 μg/mL Cameroon [117]
Melinis minutiflora P. Beauv. Poaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 58.47% at 200 μg/mL Cameroon [117]
Mimosa pudica L. Mimosaceae Leaf MeOH DPPH 19.37% Cameroon [53]
Musa sapientum L. Musaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −9.33% at 200 μg/mL Cameroon [117]
Nauclea latifolia Sm. Rubiaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 43.02% at 200 μg/mL Cameroon [117]
Occimum gratissimum L. Labieae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 68.01% at 200 μg/mL Cameroon [117]
Ocimum basilicum L. Lamiaceae Leaf MeOH DPPH 39.98% Cameroon [53]
Olax subscorpioideae Oliv. Olacaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 44.71% at 200 μg/mL Cameroon [117]
Paullinia pinnata L. Sapindaceae Leaf n-C6H12 DPPH Least activity Cameroon [272]
Pentadesma butyracea Sabine. Clusiaceae Fruits MeOH DPPH High Cameroon [272]
Persea americana MIill. Lauraceae Leaf MeOH DPPH 69.91% Cameroon [53]
Persea americana MIill. Lauraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 24.31% at 200 μg/mL Cameroon [117]
Persea americana MIill. Lauraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 44.85% at 200 μg/mL Cameroon [117]
Piliostigma thonningii MIill. Cesalpilaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 74.26% at 200 μg/mL Cameroon [117]
Polyscias fulva Harns (Hieram). Araliaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −0.01% at 200 μg/mL Cameroon [117]
Protea elliotii C.H. Wright. Proteaceae Back MeOH DPPH/NO 14.20/205 μg/mL Cameroon [269]
Protea elliotii C.H. Wright. Proteaceae Bark MeOH DPPH/NOSA 14.20/306.00 μg/mL Cameroon [269]
Prunus Africana (Hook. f.) Rosaceae Bark MeOH DPPH 22.10% Cameroon [53]
Psidium guajava L. Myrsinacee Leaf MeOH DPPH 39.84% Cameroon [53]
Psidium guayava L. Myrtaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 50.47% at 200 μg/mL Cameroon [117]
Psorospermum febrifugum Spach. Guttiferae Stem bark MeOH DPPH Least activity Cameroon [272]
Pycnocycla ledernanii Wolff. Apiaceae Leaf MeOH DPPH 8.57% Cameroon [53]
Rumex abyssinicus Jacq. Polygonaceae Bulb MeOH DPPH High activity Cameroon [272]
Rumex bequaertii De wild. Polygonaceae Bulb MeOH DPPH High activity Cameroon [272]
Senna alata L. Fabaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 88.50% at 200 μg/mL Cameroon [117]
Senna siamea Lam. Fabaceae Leaf MeOH DPPH 236 μg/mL Cameroon [269]
Senna siamea Lam. Fabaceae Leaf MeOH DPPH 236 μg/mL Cameroon [269]
Solanum acaleastrum Solanaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 28.57% at 200 μg/mL Cameroon [117]
Sonchus oleraceus L. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 31.02% at 200 μg/mL Cameroon [117]
Spilanthes filicaulis (Schum. & Thonn.) C.D. Adam. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 58.93% at 200 μg/mL Cameroon [117]
Syzyguim guineense Wall. Myrtaceae Leaf MeOH;H2O DPPH/ABTS/OH 5.52 g/mL/16.25 mg/mL/126.35 g/mL Cameroon [276]
Tectona grandis L.F. Lamiaceae Leaf MeOH DPPH Least activity Cameroon [272]
Terminalia glaucescens Planch. Combretaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 47.68% at 200 μg/mL Cameroon [117]
Terminalia macroptera Mart. Combretaceae Root MeOH DPPH/NO 19.90/290 μg/mL Cameroon [269]
Terminalia macroptera Mart. Combretaceae Root MeOH DPPH/NOSA 19.90/205.00 μg/mL Cameroon [269]
Trema orientalis Blume. Ulmaceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP −5.23% at 200 μg/mL Cameroon [117]
Urena lobata L. Malvaceae Leaf MeOH DPPH 9.70% Cameroon [53]
Vernonia amygdalina Delile. Asteraceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe (II)-Ascorbate induced LP 33.49% at 200 μg/mL Cameroon [117]
Vismia laurentii De Wild. Guttiferae Stem bark EtOAc/MeOH DPPH High Cameroon [272]
Vitellaria paradoxa C.F.Gaertn. Sapotaceae Back MeOH DPPH/NO 22.14/108 μg/mL Cameroon [269]
Voacanga africana Stapf. Apocynaceae Bark/Leaf/Rhizom MeOH;CH2Cl2 Fe(II)-Ascorbate induced LP 100.00% at 200 μg/mL Cameroon [117]
Voacanga africana Stapf. Apocynaceae Bark MeOH DPPH 3.73% Cameroon [53]
Xanthosoma sagittifolium (L.) schott. Araceae Bark/Leaf/Rhizome MeOH;CH2Cl2 Fe(II)-Ascorbate induced LP 48.01% at 200 μg/mL Cameroon [117]
Zea mays L. Poaceae Leaf MeOH DPPH 12.06% Cameroon [53]
  1. Key: RSA radical scavenging activity, RC reducing power capacity, OH hydroxyl ion, NO nitric oxide radical inhibition, H 2 O 2 hydrogen peroxide inhibition activity, LPO lipid peroxidation inhibition activity, ABTS + 2,2′-azinobis-3–ethylbenzothiozolin-6–sulfonic acid cation decolourization test, ß-CLAMS ß-carotene-linoleic acid model system, SORSA superoxide anion radical scavenging activity (SORSA), MLP microsomal lipid peroxydation, FRAP fe2+ chelating ability and ferric reducing antioxidant properties, DPPH 1,1–dipheyl-2–picry-hydrazyl, ORAC oxygen radical absorbance capacity, TEAC trolox equivalent antioxidant capacity, MeOH methanol, CH 2 Cl 2 dichloromethane, EtOH ethanol, EtOAc ethyl acetate, n-C 6 H 12 hexane, (CH 3)2 CO acetone, H 2 O aqueous, BtOH butanol