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International Journal of Phytomedicine and Phytotherapy

Table 2 Evaluation of the effect of MO leaf extract on AS-AQ intoxicated Wistar rats by using biomarkers of liver injury

From: Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

Group Treatment code (n = 3) AST (IU/L) ALT (IU/L) TB (mg/dl)
1 PBS only 122.37 ± 13.73 65.18 ± 20.08 0.83 ± 0.67
2 SCG 127.67 ± 25.07 78.95 ± 24.11 3.08 ± 1.30
3 MCG 113.93 ± 5.46* 80.73 ± 21.65 1.69 ± 0.38
4 CD-ASAQ 138.97 ± 13.14 76.44 ± 0.85 2.92 ± 2.06
5 2 × CD-ASAQ 158.8 ± 20.08 85.70 ± 17.55 1.19 ± 0.94
6 4 × CD-ASAQ 220.33 ± 53.97* 90.39 ± 13.62 2.70 ± 0.96
7 S + CD-ASAQ 130.97 ± 16.61 58.01 ± 20.16 1.15 ± 0.57
8 S + 2CD-ASAQ 125.74 ± 45.13 64.47 ± 23.65 2.00 ± 2.07
9 S + 4CD-ASAQ 184.00 ± 23.60 68.00 ± 28.83 2.93 ± 2.32
10 M + CD-ASAQ 138.77 ± 24.33 66.37 ± 13.29 0.53 ± 0.35
11 M + 2CD-ASAQ 171.13 ± 52.88 80.38 ± 21.56 1.61 ± 0.80
12 M + 4CD-ASAQ 140.03 ± 24.45* 76.77 ± 14.61 1.17 ± 0.66
  1. Values are expressed as mean ± SEM (n = 3) significantly different at *p ≤ 0.05
  2. PBS physiological buffer saline, SCG siliphos® control group, MCG moringa control group, CD-ASAQ clinical dose of artesunate-amodiaquine, 2 × CD-AS-AQ double the clinical dose of artesunate-amodiaquine, 4 × CD-ASAQ four times the clinical dose of artesunate-amodiaquine, S + CD-ASAQ pre-treatment with Siliphos®followed an hour later by treatment with a clinical dose of artesunate-amodiaquine, S + 2* CD-ASAQ pre-treatment with Siliphos® followed an hour later by treatment with double the clinical dose of ASAQ, S + 4 × CD-ASAQ pre-treatment with Siliphos® followed an hour later by treatment with four times the clinical dose of ASAQ, M + CD-ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with the clinical dose of AS-AQ, M + 2 × CD: ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with double the clinical dose of ASAQ, M + 4 × CD-ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with four times the clinical dose of AS-AQ