Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Evaluation of the effect of MO leaf extract on AS-AQ intoxicated Wistar rats by using biomarkers of liver injury

Group	Treatment code (n = 3)	AST (IU/L)	ALT (IU/L)	TB (mg/dl)
1	PBS only	122.37 ± 13.73	65.18 ± 20.08	0.83 ± 0.67
2	SCG	127.67 ± 25.07	78.95 ± 24.11	3.08 ± 1.30
3	MCG	113.93 ± 5.46*	80.73 ± 21.65	1.69 ± 0.38
4	CD-ASAQ	138.97 ± 13.14	76.44 ± 0.85	2.92 ± 2.06
5	2 × CD-ASAQ	158.8 ± 20.08	85.70 ± 17.55	1.19 ± 0.94
6	4 × CD-ASAQ	220.33 ± 53.97*	90.39 ± 13.62	2.70 ± 0.96
7	S + CD-ASAQ	130.97 ± 16.61	58.01 ± 20.16	1.15 ± 0.57
8	S + 2CD-ASAQ	125.74 ± 45.13	64.47 ± 23.65	2.00 ± 2.07
9	S + 4CD-ASAQ	184.00 ± 23.60	68.00 ± 28.83	2.93 ± 2.32
10	M + CD-ASAQ	138.77 ± 24.33	66.37 ± 13.29	0.53 ± 0.35
11	M + 2CD-ASAQ	171.13 ± 52.88	80.38 ± 21.56	1.61 ± 0.80
12	M + 4CD-ASAQ	140.03 ± 24.45*	76.77 ± 14.61	1.17 ± 0.66

Values are expressed as mean ± SEM (n = 3) significantly different at *p ≤ 0.05
PBS physiological buffer saline, SCG siliphos^® control group, MCG moringa control group, CD-ASAQ clinical dose of artesunate-amodiaquine, 2 × CD-AS-AQ double the clinical dose of artesunate-amodiaquine, 4 × CD-ASAQ four times the clinical dose of artesunate-amodiaquine, S + CD-ASAQ pre-treatment with Siliphos^®followed an hour later by treatment with a clinical dose of artesunate-amodiaquine, S + 2* CD-ASAQ pre-treatment with Siliphos^® followed an hour later by treatment with double the clinical dose of ASAQ, S + 4 × CD-ASAQ pre-treatment with Siliphos^® followed an hour later by treatment with four times the clinical dose of ASAQ, M + CD-ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with the clinical dose of AS-AQ, M + 2 × CD: ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with double the clinical dose of ASAQ, M + 4 × CD-ASAQ pre-treatment with the aqueous-methanol MO leaf extract followed an hour later by treatment with four times the clinical dose of AS-AQ