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International Journal of Phytomedicine and Phytotherapy

Table 2 The effect of MEPH on the open field test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Number of squares crossed
0 min. 30 mins. 60 mins. 90 mins. 120 mins.
Control 0.1 ml/mouse 102.80 ± 2.92 98.00 ± 2.81 97.40 ± 2.27 82.40 ± 2.69 72.00 ± 2.55
Diazepam 1 95.00 ± 1.84 27.60 ± 1.91*** 22.00 ± 1.00*** 10.60 ± 0.51*** 5.20 ± 0.66***
MEPH 50 98.20 ± 2.26 94.60 ± 2.24 92.60 ± 2.29 74.40 ± 1.47* 63.20 ± 2.31*
MEPH 200 95.40 ± 2.40 92.00 ± 2.89 90.60 ± 1.96* 72.00 ± 2.25** 58.60 ± 1.83***
MEPH 350 99.80 ± 2.43 87.00 ± 2.58** 84.20 ± 1.15*** 21.40 ± 2.11*** 15.60 ± 2.31***
MEPH 500 99.40 ± 2.42 46.40 ± 1.88*** 33.40 ± 1.47*** 22.00 ± 0.89*** 8.40 ± 0.87***
  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”