Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 The effect of MEPH on the open field test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment	Dose (mg/kg)	Number of squares crossed
Treatment	Dose (mg/kg)	0 min.	30 mins.	60 mins.	90 mins.	120 mins.
Control	0.1 ml/mouse	102.80 ± 2.92	98.00 ± 2.81	97.40 ± 2.27	82.40 ± 2.69	72.00 ± 2.55
Diazepam	1	95.00 ± 1.84	27.60 ± 1.91***	22.00 ± 1.00***	10.60 ± 0.51***	5.20 ± 0.66***
MEPH	50	98.20 ± 2.26	94.60 ± 2.24	92.60 ± 2.29	74.40 ± 1.47*	63.20 ± 2.31*
MEPH	200	95.40 ± 2.40	92.00 ± 2.89	90.60 ± 1.96*	72.00 ± 2.25**	58.60 ± 1.83***
MEPH	350	99.80 ± 2.43	87.00 ± 2.58**	84.20 ± 1.15***	21.40 ± 2.11***	15.60 ± 2.31***
MEPH	500	99.40 ± 2.42	46.40 ± 1.88***	33.40 ± 1.47***	22.00 ± 0.89***	8.40 ± 0.87***

Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”

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