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International Journal of Phytomedicine and Phytotherapy

Table 3 The effect of MEPH on hole cross test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Number of holes crossed
0 min. 30 mins. 60 mins. 90 mins. 120 mins.
Control 0.1 ml/mouse 18.00 ± 0.83 19.80 ± 0.66 21.80 ± 0.97 20.00 ± 1.30 18.40 ± 0.51
Diazepam 1 8.60 ± 0.24 8.40 ± 0.24*** 6.40 ± 0.24*** 4.20 ± 0.37*** 1.40 ± 0.74***
MEPH 50 17.60 ± 1.96 19.80 ± 2.57 17.80 ± 3.08 17.60 ± 3.10 14.80 ± 3.82*
MEPH 200 14.40 ± 1.50 16.00 ± 2.25 14.60 ± 3.86* 12.20 ± 3.23*** 10.60 ± 3.62***
MEPH 350 11.80 ± 1.62 11.80 ± 0.49** 10.80 ± 2.33*** 8.00 ± 1.81*** 5.00 ± 0.31***
MEPH 500 10.60 ± 0.24 11.00 ± 1.04*** 9.40 ± 0.24*** 6.60 ± 0.60*** 3.40 ± 0.74***
  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”