Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 The effect of MEPH on thiopental sodium-induced sleeping time test in mice

Treatment	Dose (mg/kg)	Onset of action (min)	Duration of sleeping time (min)
Control	0.1 ml/mouse	13.57 + 0.45	87.80 + 1.85
Diazepam	1	6.72 + 0.06***	187.40 + 1.12***
MEPH	50	12.10 + 0.57**	94.60 + 1.80*
MEPH	200	9.92 + 0.19***	132.80 + 1.85***
MEPH	350	8.50 + 0.22***	163.00 + 1.37***
MEPH	500	7.44 + 0.16***	176.20 + 1.35***

Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”