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International Journal of Phytomedicine and Phytotherapy

Table 5 The effect of MEPH on thiopental sodium-induced sleeping time test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Onset of action (min) Duration of sleeping time (min)
Control 0.1 ml/mouse 13.57 + 0.45 87.80 + 1.85
Diazepam 1 6.72 + 0.06*** 187.40 + 1.12***
MEPH 50 12.10 + 0.57** 94.60 + 1.80*
MEPH 200 9.92 + 0.19*** 132.80 + 1.85***
MEPH 350 8.50 + 0.22*** 163.00 + 1.37***
MEPH 500 7.44 + 0.16*** 176.20 + 1.35***
  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”