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International Journal of Phytomedicine and Phytotherapy

Table 6 The effect of MEPH on elevated plus-maze test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Time spend in open arms (s) Entries in open arms (s) Time spend in close arms (s) Entries in close arms (s)
Control 0.1 ml/mouse 119.00 ± 3.31 8.60 ± 0.98 181.00 ± 3.31 16.40 ± 0.81
Diazepam 1 253.60 ± 1.03*** 1.00*** 18.00 ± 0.94*** 46.40 ± 1.03*** 1.80 ± 0.37***
MEPH 50 177.40 ± 2.50*** 4.40 ± 0.40* 122.60 ± 2.50*** 1.80 ± 0.58
MEPH 200 171.00 ± 1.04*** 8.80 ± 0.58** 149.80 ± 1.77*** 6.60 ± 0.51
MEPH 350 195.00 ± 1.70*** 11.40 ± 0.51*** 105.00 ± 1.70*** 8.80 ± 1.02***
MEPH 500 232.40 ± 1.12*** 13.60 ± 0.60*** *** 67.60 ± 1.12*** 4.60 ± 1.32*
  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”