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International Journal of Phytomedicine and Phytotherapy

Table 6 The effect of MEPH on elevated plus-maze test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment

Dose (mg/kg)

Time spend in open arms (s)

Entries in open arms (s)

Time spend in close arms (s)

Entries in close arms (s)

Control

0.1 ml/mouse

119.00 ± 3.31

8.60 ± 0.98

181.00 ± 3.31

16.40 ± 0.81

Diazepam

1

253.60 ± 1.03*** 1.00***

18.00 ± 0.94***

46.40 ± 1.03***

1.80 ± 0.37***

MEPH

50

177.40 ± 2.50***

4.40 ± 0.40*

122.60 ± 2.50***

1.80 ± 0.58

MEPH

200

171.00 ± 1.04***

8.80 ± 0.58**

149.80 ± 1.77***

6.60 ± 0.51

MEPH

350

195.00 ± 1.70***

11.40 ± 0.51***

105.00 ± 1.70***

8.80 ± 1.02***

MEPH

500

232.40 ± 1.12***

13.60 ± 0.60*** ***

67.60 ± 1.12***

4.60 ± 1.32*

  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”