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International Journal of Phytomedicine and Phytotherapy

Table 7 The effect of MEPH on light-dark box test in mice

From: Evaluation of sedative and anxiolytic activities of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Latency time (s) Transition Time spent in the light compartment(s) Time spent in the dark compartment(s)
Control 0.1 ml/mouse 31.00 ± 0.83 20.40 ± 0.67 248.80 ± 1.71 51.20 ± 2.43
Diazepam 1 10.00 ± 0.31*** 7.00 ± 0.44*** 92.60 ± 1.43*** 207.40 ± 1.43***
MEPH 50 28.20 ± 0.37 19.40 ± 0.40 226.80 ± 1.82*** 72.20 ± 1.15***
MEPH 200 26.00 ± 0.31*** 16.40 ± 0.67*** 225.00 ± 1.58*** 105.00 ± 1.58***
MEPH 350 21.00 ± 0.31*** 11.40 ± 0.98*** 149.20 ± 1.80*** 105.60 ± 1.16***
MEPH 500 13.80 ± 0.73*** 9.80 ± 0.37*** 101.80 ± 1.39*** 198.20 ± 1.39***
  1. Each value is presented as the mean ± SEM (n = 10), MEPH = Methanol extract of Persicaria hydropiper leaves. “***p < 0.001, **p < 0.01, *p < 0.05 vs control group (Dunnett’s test)”