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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of C. diffusa extract and diazepam on the open field test

From: Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Treatment

Dose

(mg/kg)

Number of square crossed

0 min

30 min

60 min

90 min

120 min

Control

0.1 mL/mouse

76.00 ± 1.64

72.20 ± 3.48

61.00 ± 2.66

41.40 ± 1.07

32.60 ± 1.36

Diazepam

1

71.80 ± 3.26

55.80 ± 2.69*

30.40 ± 2.04*

15.00 ± 0.70*

6.80 ± 0.58*

MECD

50

59.80 ± 1.96

49.00 ± 4.19*

44.00 ± 1.22*

27.60 ± 1.12*

15.40 ± 0.74*

MECD

100

56.40 ± 2.42

43.20 ± 1.28*

40.40 ± 2.06*

19.60 ± 0.92*

9.80 ± 0.66*

MECD

200

63.60 ± 1.93

51.00 ± 1.76*

33.60 ± 1.83*

17.40 ± 0.92*

8.20 ± 0.58*

  1. Values are presented as mean ± SEM (n = 5). MECD = Methanolic extract of C. diffusa
  2. * p < 0.05, vs. control (Dunnett’s test)