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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 6 Effects of C. diffusa extract and diazepam on thiopental sodium-induced sleeping time test

From: Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Treatment

Dose (mg/kg)

Onset of action (min)

Duration of sleeping time (min)

Control

0.1 mL/mouse

4.95 ± 0.41

27.00 ± 1.92

Diazepam

1

3.01 ± 0.13*

91.20 ± 1.93*

MECD

50

4.78 ± 0.22

38.80 ± 1.36*

MECD

100

4.56 ± 0.22

46.80 ± 1.28*

MECD

200

3.74 ± 0.24*

76.20 ± 2.15*

  1. Values are presented as mean ± SEM (n = 5). MECD = Methanolic extract of C. diffusa
  2. * p < 0.05, vs. control (Dunnett’s test)
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