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International Journal of Phytomedicine and Phytotherapy

Table 1 Anticholinesterase activity of solvent fractions of S. dasyphyllum in rats cerebrocortex exposed to potassium cyanide

From: Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase

 

Acetylcholilnesterase activity (umole of acetylcholine hydrolyzed/min/mg protein)

Concentration (μg/ml)

HFSD

DFSD

EAFSD

MFSD

CFSD

Control

0.44 ± 0.045

0.44 ± 0.045

0.44 ± 0.045

0.44 ± 0.045

0.44 ± 0.045

KCN

0.95 ± 0.06

0.95 ± 0.06

0.95 ± 0.06

0.95 ± 0.06

0.95 ± 0.06

5

0.61 ± 0.08(35.79%)

0.605 ± 0.05(36.32%)

0.76 ± 0.10(20%)

0.635 ± 0.9(33.16%)

0.61 ± 0.08(35.79%)

10

0.59 ± 0.06(37.89%)

0.605 ± 0.06(36.32%)

0.925 ± 0.09(2.63%)

0.6 ± 0.08(36.84%)

0.6 ± 0.07(36.84%)

20

0.63 ± 0.1(30.52%)

0.605 ± 0.08(36.32%)

1.06 ± 0.14(−11.58%)

0.595 ± 0.087(37.37%)

0.59 ± 0.1(37.89%)

30

0.66 ± 0.1(30.53%)

0.605 ± 0.08(36.32%)

0.89 ± 0.09(6.32%)

0.59 ± 0.08(37.89%)

0.59 ± 0.07(37.89%)

40

0.65 ± 0.07(31.58%)

0.6 ± 0.09(36.84%)

0.62 ± 0.08(34.74%)

0.595 ± 0.08(37.37%)

0.6 ± 0.09(36.84%)

50

0.59 ± 0.07(37.89%)

0.605 ± 0.08(36.32%)

0.6 ± 0.06(36.84%)

0.635 ± 0.1(33.16%)

0.59 ± 0.09(37.89%)

  1. Results are expressed as means±SD (n = 3)
  2. HFSD Hexane fraction of Solanum dasyphyllum, DFSD Dichloromethane fraction of Solanum dasyphyllum, EAFSD Ethyl Acetate fraction of Solanum dasyphyllum, MFSD Methanol fraction of Solanum dasyphyllum, CFSD Crude fraction of Solanum dasyphyllum
  3. * percentage increase in activity as compared to toxicant