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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of solvent fractions of S. dasyphyllum on Succinate- cytochrome c reductase in rat cerebrocortex exposed to potassium cyanide

From: Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase

 

Succinate cytochrome c reductase activity (nmol of cytochrome c reduced/min/mg protein)

Concentration (μg/ml)

HFSD

DFSD

EAFSD

MFSD

CFSD

Control

0.155 ± 0.04

0.155 ± 0.04

0.155 ± 0.04

0.155 ± 0.04

0.155 ± 0.04

KCN

0.085 ± 0.002

0.085 ± 0.002

0.085 ± 0.002

0.085 ± 0.002

0.085 ± 0.002

5

0.145 ± 0.3(70.59%)

0.08 ± 0.017(−5.88%)

0.135 ± 0.019(58.82%)

0.16 ± 0.03(88.24%)

0.15 ± 0.03(76.47%)

10

0.285 ± 0.041(235.29%)

0.07 ± 0.001(−17.65%)

0.21 ± 0.051(147.06%)

0.205 ± 0.207(141.17%)

0.13 ± 0.03(52.94%)

20

0.15 ± 0.041(76.47%)

0.06 ± 0.02(−29.41%)

0.14 ± 0.03(64.71%)

0.145 ± 0.03(70.59%)

0.125 ± 0.042(47.06%)

30

0.14 ± 0.03(64.71%)

0.09 ± 0.01(5.88%)

0.16 ± 0.05(88.24%)

0.22 ± 0.03(158.82%)

0.155 ± 0.021(82.35%)

40

0.165 ± 0.03(94.12%)

0.075 ± 0.006(−11.76%)

0.175 ± 0.03(105.88%)

0.135 ± 0.019(58.82%)

0.13 ± 0.01(52.94%)

50

0.175 ± 0.03(105.88%)

0.085 ± 0.0215(0%)

0.155 ± 0.04(82.35%)

0.135 ± 0.02(58.82%)

0.155 ± 0.02(82.35%)

  1. Results are expressed as means±SD (n = 3)
  2. HFSD Hexane fraction of Solanum dasyphyllum, DFSD Dichloromethane fraction of Solanum dasyphyllum, EAFSD Ethyl Acetate fraction of Solanum dasyphyllum, MFSD Methanol fraction of Solanum dasyphyllum, CFSD Crude fraction of Solanum dasyphyllum
  3. * percentage increase in activity as compared to toxicant