International Journal of Phytomedicine and Phytotherapy
Table 1 Results of the anti-inflammatory activity of the total ethanolic extract and different fractions of A. hirtum leave using carrageenan – induced paw edema method
Group | Thickness of the paw (mm) | ||||||
|---|---|---|---|---|---|---|---|
0 h | 30 min | 1 h | 2 h | 3 h | 4 h | 5 h | |
Control (−ve) | 7.37 ± 0. 12 | 7.37 ± 0.12 | 7.5 ± 0.0 | 7.62 ± 0.12 | 7.62 ± 0.12 | 7.87 ± 0.23 | 7.87 ± 0.23 |
Total extract (300 mg/kg) | 7.25 ± 0.14 | 6.87 ± 0. 12 | 6.25 ± 0.14*** | 5.62 ± 0.23*** | 4.62 ± 0.23*** | 4.0 ± 0.20*** | 3.87 ± 0.12*** |
Petroleum ether fraction (300 mg/kg) | 7.25 ± 0.14 | 7.12 ± 0.12 | 6.75 ± 0.14* | 6.37 ± 0.23** | 5.75 ± 0.32*** | 5.25 ± 0.25*** | 4.87 ± 0.12*** |
Chloroform fraction (300 mg/kg) | 7.25 ± 0.14 | 6.62 ± 0.23* | 6.37 ± 0.23*** | 5.62 ± 0.23*** | 4.87 ± 0.31*** | 4.0 ± 0.2*** | 3.87 ± 0.12*** |
Ethyl acetate fraction (300 mg/kg) | 7.25 ± 0.14 | 7.0 ± 0.0 | 6.75 ± 0.14* | 6.5 ± 0.2** | 5.87 ± 0.12*** | 5.37 ± 0.37*** | 5.37 ± 0.37*** |
Aqueous fraction (300 mg/kg) | 7.12 ± 0. 12 | 7.12 ± 0.12 | 6.75 ± 0.14* | 6.5 ± 0.2** | 6.0 ± 0.20*** | 4.87 ± 0.12*** | 4.75 ± 0.14*** |
Indomethacin (8 mg/kg) | 7.25 ± 0.14 | 6.5 ± 0.2** | 6.0 ± 0.20*** | 5.62 ± 0.23*** | 5.37 ± 0.23*** | 4.12 ± 0.12*** | 3.75 ± 0.14*** |