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International Journal of Phytomedicine and Phytotherapy

Table 5 Results of the antipyretic activity of the total ethanolic extract and different fractions of A. hirtum leaves on yeast–induced pyrexia method

From: Anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Abutilon hirtum (Lam.) Sweet

Group Rectal temperature (°C)   
  0 h 30 min 1 h 2 h 3 h 4 h 5 h
Control (−ve) 38.73 ± 0.08 38.85 ± 0.02 38.85 ± 0.05 38.88 ± 0.02 39.55 ± 0.13 39.9 ± 0.04 39.98 ± 0.08***
Total extract (300 mg/kg) 38.63 ± 0.10 38.2 ± 0.07*** 37.3 ± 0.09*** 36.35 ± 0.06 *** 36.23 ± 0.04*** 36.13 ± 0.04*** 36.05 ± 0.02***
Petroleum ether fraction (300 mg/kg) 38.68 ± 0.08 38.23 ± 0.12*** 38.15 ± 0.02*** 37.33 ± 0.10*** 37.4 ± 0.17*** 37.13 ± 0.07*** 37.1 ± 0.04***
Chloroform fraction (300 mg/kg) 38.7 ± 0.09 38.73 ± 0.04 38.63 ± 0.04 38.5 ± 0.04*** 38.43 ± 0.04*** 38.48 ± 0.04*** 38.5 ± 0.04***
Ethyl acetate fraction (300 mg/kg) 38.75 ± 0.09 38.5 ± 0.04* 38.2 ± 0.07*** 37.63 ± 0.06*** 37.55 ± 0.06*** 37.2 ± 0.04*** 37.05 ± 0.02***
Aqueous fraction (300 mg/kg) 38.73 ± 0.06 38.43 ± 0.08** 38 ± 0.13*** 37.48 ± 0.02*** 37.43 ± 0.04*** 37.25 ± 0.11*** 37.13 ± 0.07***
Acetylsalicylic acid (100 mg/kg) 38.78 ± 0.07 38.48 ± 0.06** 37.7 ± 0.16*** 37.43 ± 0.04*** 37.2 ± 0.04*** 37.2 ± 0.07*** 37.15 ± 0.02***
  1. The results are presented as the mean ± S.E.M Standard error of the mean. Differences with respect to the control group were calculated using the student’s T-test (*P < 0.05, **P < 0.01, ***P < 0.001)