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International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of methanolic extract of the L. sativus L. seeds on hole cross test in mice

From: Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Group

Number of Movements (Mean ± SEM)

0 min

30 min

60 min

90 min

120 min

Group-I

11.75 ± 1.11

27.00 ± 2.45

19.50 ± 2.22

18.50 ± 1.19

20.00 ± 2.39

Group-II

6.50 ± 1.32*

11.00 ± 1.58**

5.25 ± 1.37**

9.00 ± 0.58***

2.50 ± 0.29***

Group-III

2.25 ± 0.48***

9.50 ± 1.08**

6.25 ± 1.03**

4.00 ± 0.41***

2.50 ± 0.64***

Group-IV

4.00 ± 0.91**

6.50 ± 0.87***

4.00 ± 0.71***

2.25 ± 0.29***

1.25 ± 0.25***

  1. Values are represented as mean ± SEM, (n = 5). Group I (control) animals received vehicle (1% Tween 80 in water), Group II (standard) received diazepam 1 mg/kg body weight, Group III and Group IV were treated with 200 and 300 mg/kg body weight (p.o.) of the methanolic extract of L. sativus L. seeds, respectively. ***indicates P < 0.001, **indicates P < 0.01 and *indicates P < 0.05; one-way ANOVA followed by Dunnett’s test as compared to control