Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of methanol extract of T. conophorum seeds on Liver Antioxidant Status in CCl₄ induced hepatotoxicity in rats after 48 h of intoxication

Values are Mean ± SD, n = 4 rats in each group. *P˂0.05; **p < 0.01; ***p < 0.001, a as compared with the normal saline (control) group; b as compared with the CCl₄ only group SOD Superoxide dismutase; CAT Catalase; GSH Reduced glutathione; GPx Glutathione peroxidase; GST Glutathione-S-Transferase,CCl₄ Carbon tetrachloride
Group IB (control) received distilled water and olive oil (i.p), group IIB rats were intoxicated with CCl₄ in olive oil (600 mg/kg, i.p.) only on the 8th day, while groups IIIB, IVB and VB were given 100 mg/kg of silymarin, 250 mg/kg and 500 mg/kg of methanol extract respectively for 7 days, thereafter intoxicated with CCl₄ on the 8th day. Groups VIB and VIIB were intoxicated with CCl₄ on the 8th day and administered 250 mg/kg and 500 mg/kg of methanol extract of T. conophorum seeds at 1 h, 6 h, 12 h, 18 h and 24 h.Fasting blood samples were collected after the last administration of the extract at 48 h of intoxication with CCl₄