Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of methanol extract of T. conophorum seeds on Liver Antioxidant Status in CCl4 induced hepatotoxicity in rats after 48 h of intoxication

From: Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats

Treatment Parameters
(n = 5) Catalase (Unit/mg protein) SOD (Unit/mg protein) GPx (Unit/mg protein) GST (Unit/mg protein GSH (μg/mg protein)
Group1B:Normal control 70.20 ± 3.50 6.70 ± 0.53 3.80 ± 0.16 0.62 ± 0.02 16.80 ± 0.53
Group IIB ***44.50 ± 1.20a ***2.50 ± 0.50a ***1.50 ± 0.06a ***0.29 ± 0.001a ***7.01 ± 0.50a
Group IIIB ***70.50 ± 2.50b ***6.50 ± 0.25b ***4.40 ± 0.15b ***0.51 ± 0.06b ***17.02 ± 0.25b
Group IVB 50.00 ± 1.17b *4.20 ± 0.20b ***3.46 ± 0.10b 0.26 ± 0.01a ***10.20 ± 0.15b
Group VB ***66.90 ± 2.00b ***6.05 ± 0.15b ***3.43 ± 0.21b **0.43 ± 0.001b ***15.20 ± 0.40b
Group VIB 48.50 ± 3.80b 2.62 ± 0.60b ***2.69 ± 0.07b 0.30 ± 0.003b ***11.80 ± 0.30b
Group VIIB ***68.00 ± 2.55b ***5.50 ± 0.11b **3.12 ± 0.20 **0.45 ± 0.02b ***14.00 ± 0.28b
  1. Values are Mean ± SD, n = 4 rats in each group. *P˂0.05; **p < 0.01; ***p < 0.001, a as compared with the normal saline (control) group; b as compared with the CCl4 only group SOD Superoxide dismutase; CAT Catalase; GSH Reduced glutathione; GPx Glutathione peroxidase; GST Glutathione-S-Transferase,CCl4 Carbon tetrachloride
  2. Group IB (control) received distilled water and olive oil (i.p), group IIB rats were intoxicated with CCl4 in olive oil (600 mg/kg, i.p.) only on the 8th day, while groups IIIB, IVB and VB were given 100 mg/kg of silymarin, 250 mg/kg and 500 mg/kg of methanol extract respectively for 7 days, thereafter intoxicated with CCl4 on the 8th day. Groups VIB and VIIB were intoxicated with CCl4 on the 8th day and administered 250 mg/kg and 500 mg/kg of methanol extract of T. conophorum seeds at 1 h, 6 h, 12 h, 18 h and 24 h.Fasting blood samples were collected after the last administration of the extract at 48 h of intoxication with CCl4