Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of S. nigrum on CCl₄ -induced changes in body weight (gm) of mice

Experimental groups	Days of treatment
Experimental groups	0	30
Control
1. Untreated	32.87 ± 1.65	34.99 ± 1.67
2. Olive oil	32.04 ± 0.15	34.74 ± 0.94
3. S. nigrum (SN)	32.49 ± 0.94	34.93 ± 1.32
Carbon Tetrachloride (CCl₄) -Treated
4. CCl₄	32.52 ± 1.23^a*	27.43 ± 1.59^a*
CCl₄ + Solanum Nigrum (SN) Extract-Treated
5. CCl₄ + SN100	33.03 ± 1.32 ^b*	30.11 ± 0.99^b*
6. CCl₄ + SN200	32.66 ± 1.12 ^b*	31.13 ± 0.45^b*
7. CCl₄ + SN300	33.04 ± 0.98 ^b*	33.82 ± 0.53^b*

Results are expressed as mean ± SEM; n = 10
No significant difference was noted between groups 1–3
^aas compared between vehicle control (group 2) and toxin-treated (group 4),
^bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
Level of significance ^*p < 0.001