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International Journal of Phytomedicine and Phytotherapy

Clinical Phytoscience Cover Image

Table 2 Effect of S. nigrum on CCl4 -induced changes in enzymatic parameters in mice liver

From: Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Experimental groups ALT AST ALP ACP
Control
 1. Untreated 1.69 ± 0.16 1.94 ± 0.39 0.27 ± 0.08 1.28 ± 0.72
 2. Olive oil 1.60 ± 0.18 1.95 ± 0.27 0.28 ± 0.06 1.27 ± 0.54
 3. S. nigrum (SN) 1.56 ± 0.13 1.96 ± 0.22 0.30 ± 0.09 1.28 ± 0.11
Carbon Tetrachloride (CCl4) -Treated
 4. CCl4 3.89 ± 0.23a* 4.61 ± 0.81 a* 0.59 ± 0.08a* 2.89 ± 0.44a*
(V) CCl4 + Solanum Nigrum (SN) Extract-Treated
 5. CCl4 + SN100 2.78 ± 0.32b* 3.80 ± 0.98b* 0.36 ± 0.07b* 1.94 ± 0.33b*
 6. CCl4 + SN200 2.51 ± 0.32b* 3.59 ± 0.32b* 0.35 ± 0.09b* 1.88 ± 0.12b*
 7. CCl4 + SN300 2.09 ± 0.66b* 2.73 ± 0.21b* 0.33 ± 0.11b* 1.58 ± 0.43b*
  1. Results are expressed as mean ± SEM; n = 10
  2. No significant difference was noted between groups 1–3
  3. aas compared between vehicle control (group 2) and toxin-treated (group 4),
  4. bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
  5. Level of significance *p < 0.001
  6. Units: ALT - mU/mg protein/30 min; AST - mU/mg protein/60 min; ALP - μmoles p-nitrophenol released/mg protein/30 min; ACP - μmoles p-nitrophenol released/mg protein/30 min