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International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of S. nigrum on CCl4 -induced changes in enzymatic parameters in mice liver

From: Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Experimental groups

ALT

AST

ALP

ACP

Control

 1. Untreated

1.69 ± 0.16

1.94 ± 0.39

0.27 ± 0.08

1.28 ± 0.72

 2. Olive oil

1.60 ± 0.18

1.95 ± 0.27

0.28 ± 0.06

1.27 ± 0.54

 3. S. nigrum (SN)

1.56 ± 0.13

1.96 ± 0.22

0.30 ± 0.09

1.28 ± 0.11

Carbon Tetrachloride (CCl4) -Treated

 4. CCl4

3.89 ± 0.23a*

4.61 ± 0.81 a*

0.59 ± 0.08a*

2.89 ± 0.44a*

(V) CCl4 + Solanum Nigrum (SN) Extract-Treated

 5. CCl4 + SN100

2.78 ± 0.32b*

3.80 ± 0.98b*

0.36 ± 0.07b*

1.94 ± 0.33b*

 6. CCl4 + SN200

2.51 ± 0.32b*

3.59 ± 0.32b*

0.35 ± 0.09b*

1.88 ± 0.12b*

 7. CCl4 + SN300

2.09 ± 0.66b*

2.73 ± 0.21b*

0.33 ± 0.11b*

1.58 ± 0.43b*

  1. Results are expressed as mean ± SEM; n = 10
  2. No significant difference was noted between groups 1–3
  3. aas compared between vehicle control (group 2) and toxin-treated (group 4),
  4. bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
  5. Level of significance *p < 0.001
  6. Units: ALT - mU/mg protein/30 min; AST - mU/mg protein/60 min; ALP - μmoles p-nitrophenol released/mg protein/30 min; ACP - μmoles p-nitrophenol released/mg protein/30 min