Skip to main content

Advertisement

International Journal of Phytomedicine and Phytotherapy

Clinical Phytoscience Cover Image

Table 3 Effect of S. nigrum on CCl4 -induced biochemical changes in serum of mice

From: Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Experimental groups ALT AST ALP ACP LDH γ-GT
Control
 1. Control 12.67 ± 0.35 39.67 ± 0.78 0.44 ± 0.02 0.21 ± 0.07 0.86 ± 0.09 0.78 ± 0.61
 2. Olive oil 12.59 ± 0.43 39.72 ± 0.13 0.43 ± 0.08 0.20 ± 0.05 0.85 ± 0.01 0.78 ± 0.18
 3. S. nigrum 12.28 ± 0.41 39.94 ± 0.16 0.44 ± 0.15 0.21 ± 0.07 0.86 ± 0.45 0.79 ± 0.13
Carbon Tetrachloride Treated (CCl4) -Treated
 4. CCl4 48.78 ± 1.08a* 96.58 ± 1.72a* 0.79 ± 0.12a* 0.36 ± 0.03a* 1.98 ± 0.32a* 1.57 ± 0.21a*
CCl4 + Solanum Nigrum (SN) Extract -Treated
 5. CCl4 + SN100 23.15 ± 0.04b* 63.25 ± 0.98b* 0.62 ± 0.05b* 0.29 ± 0.06b* 1.64 ± 0.11b* 1.43 ± 0.56b*
 6. CCl4 + SN200 17.62 ± 0.76b* 53.14 ± 1.09b* 0.59 ± 0.07b* 0.27 ± 0.07b* 1.58 ± 0.56b* 1.32 ± 0.65b*
 7. CCl4 + SN300 14.63 ± 0.66b* 48.40 ± 1.11b* 0.53 ± 0.04b* 0.24 ± 0.07b* 1.42 ± 0.98b* 1.03 ± 0.32b*
  1. Results are expressed as mean ± SEM; n = 10
  2. No significant difference was noted between groups 1–3
  3. aas compared between vehicle control (group 2) and toxin-treated (group 4),
  4. bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
  5. Level of significance *p < 0.001
  6. Units: ALT - mU/mL; AST - mU/mL; ALP - μmoles p-nitrophenol released/mg protein/30 min; ACP - μ moles p-nitrophenol released/mg protein/30 min; LDH - μmoles pyruvate liberated/mg protein/min; γ-GT - μmoles p-nitroaniline liberated/mg protein/min