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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of S. nigrum on CCl4 -induced biochemical changes in serum of mice

From: Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Experimental groups

ALT

AST

ALP

ACP

LDH

γ-GT

Control

 1. Control

12.67 ± 0.35

39.67 ± 0.78

0.44 ± 0.02

0.21 ± 0.07

0.86 ± 0.09

0.78 ± 0.61

 2. Olive oil

12.59 ± 0.43

39.72 ± 0.13

0.43 ± 0.08

0.20 ± 0.05

0.85 ± 0.01

0.78 ± 0.18

 3. S. nigrum

12.28 ± 0.41

39.94 ± 0.16

0.44 ± 0.15

0.21 ± 0.07

0.86 ± 0.45

0.79 ± 0.13

Carbon Tetrachloride Treated (CCl4) -Treated

 4. CCl4

48.78 ± 1.08a*

96.58 ± 1.72a*

0.79 ± 0.12a*

0.36 ± 0.03a*

1.98 ± 0.32a*

1.57 ± 0.21a*

CCl4 + Solanum Nigrum (SN) Extract -Treated

 5. CCl4 + SN100

23.15 ± 0.04b*

63.25 ± 0.98b*

0.62 ± 0.05b*

0.29 ± 0.06b*

1.64 ± 0.11b*

1.43 ± 0.56b*

 6. CCl4 + SN200

17.62 ± 0.76b*

53.14 ± 1.09b*

0.59 ± 0.07b*

0.27 ± 0.07b*

1.58 ± 0.56b*

1.32 ± 0.65b*

 7. CCl4 + SN300

14.63 ± 0.66b*

48.40 ± 1.11b*

0.53 ± 0.04b*

0.24 ± 0.07b*

1.42 ± 0.98b*

1.03 ± 0.32b*

  1. Results are expressed as mean ± SEM; n = 10
  2. No significant difference was noted between groups 1–3
  3. aas compared between vehicle control (group 2) and toxin-treated (group 4),
  4. bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
  5. Level of significance *p < 0.001
  6. Units: ALT - mU/mL; AST - mU/mL; ALP - μmoles p-nitrophenol released/mg protein/30 min; ACP - μ moles p-nitrophenol released/mg protein/30 min; LDH - μmoles pyruvate liberated/mg protein/min; γ-GT - μmoles p-nitroaniline liberated/mg protein/min