Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of S. nigrum on CCl₄ -induced biochemical changes in liver of mice

Experimental groups	DNA	RNA	Protein
Control
1. Untreated	483.09 ± 5.68	326.15 ± 2.25	22.08 ± 1.23
2. Olive oil	483.61 ± 6.32	324.82 ± 1.67	22.14 ± 1.43
3. S. nigrum (SN)	482.91 ± 0.99	325.75 ± 4.45	22.89 ± 0.54
Car Carbon Tetrachloride (CCl4) -Treated
4. CCl4	342.90 ± 2.65^a*	251.69 ± 2.7 8 ^{a *}	13.67 ± 0.87 ^a*
(V) C CCl4 + Solanum Nigrum Extract (SN) –Treated
5. CCl4 + SN100	369.51 ± 1.87^b*	265.19 ± 0.95^b*	18.19 ± 0.55^b*
6. CCl4 + SN200	400.14 ± 1.21^b*	280.14 ± 1.09^b*	19.89 ± 0.98^b*
7. CCl4 + SN300	419.72 ± 0.76^b*	292.04 ± 1.21^b*	21.13 ± 0.88^b*

Results are expressed as mean ± SEM; n = 10
No significant difference was noted between groups 1–3
^aas compared between vehicle control (group 2) and toxin-treated (group 4),
^bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
Level of significance ^*p < 0.001
Units: DNA - μmoles/100 mg tissue weight; RNA - μmoles/100 mg tissue weight; Protein – mg/100 mg tissue weight