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International Journal of Phytomedicine and Phytotherapy

Clinical Phytoscience Cover Image

Table 4 Effect of S. nigrum on CCl4 -induced biochemical changes in liver of mice

From: Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

Experimental groups DNA RNA Protein
Control
 1. Untreated 483.09 ± 5.68 326.15 ± 2.25 22.08 ± 1.23
 2. Olive oil 483.61 ± 6.32 324.82 ± 1.67 22.14 ± 1.43
 3. S. nigrum (SN) 482.91 ± 0.99 325.75 ± 4.45 22.89 ± 0.54
Car Carbon Tetrachloride (CCl4) -Treated
 4. CCl4 342.90 ± 2.65a* 251.69 ± 2.7 8 a * 13.67 ± 0.87 a*
(V) C CCl4 + Solanum Nigrum Extract (SN) –Treated
 5. CCl4 + SN100 369.51 ± 1.87b* 265.19 ± 0.95b* 18.19 ± 0.55b*
 6. CCl4 + SN200 400.14 ± 1.21b* 280.14 ± 1.09b* 19.89 ± 0.98b*
 7. CCl4 + SN300 419.72 ± 0.76b* 292.04 ± 1.21b* 21.13 ± 0.88b*
  1. Results are expressed as mean ± SEM; n = 10
  2. No significant difference was noted between groups 1–3
  3. aas compared between vehicle control (group 2) and toxin-treated (group 4),
  4. bas compared between toxin-treated (group 4) and toxin + antidote-treated (groups 5–7)
  5. Level of significance *p < 0.001
  6. Units: DNA - μmoles/100 mg tissue weight; RNA - μmoles/100 mg tissue weight; Protein – mg/100 mg tissue weight