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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of ARELE on haematological parameters in both male and female rats treated for 30 days

From: Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb., leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote

Sex Parameter Unit Control ARELE (mg/kg, b.wt.)
125 250 500
Male
 Haemoglobin gms/dL 13.64 ± 0.53 14.45 ± 0.69 12.58 ± 1.62 11.87 ± 1.04*
 WBC 103/μL 8.89 ± 2.22 9.46 ± 0.95 11.86 ± 1.89* 11.42 ± 1.94
 RBC 106/μL 8.22 ± 0.45 8.31 ± 0.61 8.33 ± 0.41 8.765 ± 0.21
 Haematocrit (HCT) % 38.33 ± 4.92 40.41 ± 4.17 45.83 ± 6.45* 46.17 ± 4.15*
 Platelets (PLT) 105/mm3 7.87 ± 0.66 7.83 ± 0.21 8.033 ± 0.36 8.27 ± 0.49
 Mean corpuscular volume (MCV) fL 52.46 ± 2.71 50.38 ± 2.80 50.28 ± 3.49 52.99 ± 2.53
 Mean corpuscular haemoglobin (MCH) pg 17.73 ± 0.91 17.95 ± 0.88 17.36 ± 0.46 17.93 ± 0.74
 Mean corpuscular hemoglobin concentration (MCHC) % 29.11 ± 1.81 29.01 ± 2.48 29.2 ± 2.87 26.4 ± 2.51
 Differential leucocyte count
  Neutrophils % 20.5 ± 6.92 18.67 ± 5.82 24.33 ± 5.82 23.83 ± 4.02
  Lymphocytes % 73.67 ± 7.09 72.5 ± 6.09 74 ± 6.13 73.16 ± 3.97
  Eosinophils % 1.5 ± 0.83 2.33 ± 1.03 4.67 ± 1.51** 4.33 ± 0.81**
  Monocytes % 2.83 ± 1.33 2.5 ± 1.05 2.17 ± 1.17 2.66 ± 1.75
Female
 Haemoglobin gms/dL 13.66 ± 0.86 13.41 ± 0.61 13.80 ± 0.71 14.13 ± 0.68
 WBC 103/μL 8.19 ± 1.78 8.25 ± 1.13 7.90 ± 1.35 7.17 ± 1.18
 RBC 106/μL 7.34 ± 0.70 7.39 ± 0.56 7.30 ± 0.51 7.99 ± 0.44
 Haematocrit (HCT) % 41.51 ± 2.74 41.19 ± 2.72 39.96 ± 2.92 43.49 ± 1.76
 Platelets (PLT) 105/mm3 7.54 ± 0.45 6.065 ± 0.52** 4.34 ± 0.47** 3.055 ± 0.35**
 Mean corpuscular volume (MCV) fL 53.18 ± 3.71 53.39 ± 3.57 54.16 ± 4.11 58.64 ± 2.79*
 Mean corpuscular haemoglobin (MCH) pg 18.08 ± 1.40 19.36 ± 1.17 18.51 ± 1.88 20.61 ± 1.31*
 Mean corpuscular hemoglobin concentration (MCHC) % 33.72 ± 2.11 32.21 ± 2.31 32.18 ± 1.70 34.15 ± 1.58
 Differential leucocyte count
  Neutrophils % 20.93 ± 4.33 32.51 ± 3.04** 37.93 ± 5.43** 51.21 ± 4.47**
  Lymphocytes % 71.82 ± 5.76 53.75 ± 5.62** 49.5 ± 4.31** 41.46 ± 4.79**
  Eosinophils % 1.64 ± 0.77 3.13 ± 1.15 2.65 ± 1.36 4.5 ± 0.77**
  Monocytes % 2.61 ± 0.55 2.50 ± 0.66 2.76 ± 0.30 2.57 ± 0.48
  1. Values are expressed as mean ± S.D. (n = 6). Statistical analysis done by one-way ANOVA followed by Dunnet’s t-test
  2. **P < 0.01 compared to control group
  3. *P < 0.05 compared to control group