Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of ARELE on biochemical parameters in both male and female rats treated for 30 days

From: Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb., leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote

Sex Parameter Unit Control ARELE (mg/kg, b.wt.)
125 250 500
Male
 Glucose mg/dL 73.82 ± 5.11 75.18 ± 4.22 75.59 ± 4.24 80.99 ± 1.46*
 Creatinine mg/dL 0.48 ± 0.14 0.65 ± 0.11 0.70 ± 0.20 0.88 ± 0.14**
 Urea mg/dL 34.78 ± 2.88 29.83 ± 2.64* 28.68 ± 2.51** 28.09 ± 2.94**
 Sodium mmol/L 146.97 ± 14.61 145.73 ± 12.90 144.10 ± 8.38 147.23 ± 5.11
 Potassium mmol/L 6.27 ± 1.85 6.56 ± 1.17 6.10 ± 1.18 5.64 ± 0.76
 Chloride mmol/L 110.82 ± 8.53 106.83 ± 5.14 111.04 ± 6.11 109.69 ± 9.50
 Total protein g/dL 6.52 ± 0.41 6.01 ± 0.20** 5.90 ± 0.16** 5.92 ± 0.16**
 Albumin g/dL 3.51 ± 0.31 3.29 ± 0.35 3.54 ± 0.29 3.76 ± 0.21
 Globulin mg/dL 2.86 ± 0.20 2.64 ± 0.42 2.87 ± 0.58 2.43 ± 0.32
 Bilirubin
  Bilirubin (T) mg/dL 0.76 ± 0.20 0.79 ± 0.23 0.79 ± 0.15 0.75 ± 0.12
  Bilirubin (D) mg/dL 0.08 ± 0.02 0.103 ± 0.02 0.106 ± 0.02 0.111 ± 0.04
 SGPT IU/L 33.10 ± 5.62 32.04 ± 5.21 29.06 ± 2.96 26.94 ± 4.00
 SGOT IU/L 63.95 ± 7.76 65.11 ± 4.39 59.79 ± 5.99 48.51 ± 3,48**
 ALP IU/L 145.94 ± 11.13 143.51 ± 7.16 136.51 ± 11.82 122.36 ± 6.88**
 Triglyceride (TG) mg/dL 80.40 ± 10.17 94.34 ± 6.97* 99.20 ± 6.94** 98.001 ± 5.20**
 Cholesterol
  Total cholesterol mg/dL 64.5 ± 5.90 108.64 ± 8.44** 128.3 ± 6.74** 135.33 ± 6.58**
  HDL cholesterol mg/dL 31.40 ± 2.39 35.86 ± 3.91* 37.49 ± 3.18** 38.77 ± 2.06**
  LDL cholesterol mg/dL 31.59 ± 2.86 30.27 ± 1.66 31.18 ± 2.05 32.69 ± 2.44
  VLDL cholesterol mg/dL 15.45 ± 1.49 15.75 ± 2.13 18.12 ± 1.19* 20.99 ± 1.38**
Female
 Glucose mg/dL 86.59 ± 7.01 80.88 ± 3.81 76.23 ± 5.81* 72.68 ± 7.03**
 Creatinine mg/dL 0.61 ± 0.19 0.78 ± 0.12 0.7 ± 0.12 0.86 ± 0.06**
 Urea mg/dL 41.40 ± 7.75 28.75 ± 3.00** 30.45 ± 2.21** 26.99 ± 3.58**
 Sodium mmol/L 142.006 ± 4.80 140.15 ± 1.51 140.05 ± 3.81 141.07 ± 2.56
 Potassium mmol/L 6.39 ± 1.49 6.46 ± 0.51 6.27 ± 0.41 6.07 ± 0.23
 Chloride mmol/L 104.57 ± 6.76 107.09 ± 4.80 105.96 ± 5.62 106.03 ± 5.83
 Total protein g/dL 6.30 ± 0.45 6.11 ± 0.41 6.13 ± 0.39 5.96 ± 0.21
 Albumin g/dL 3.93 ± 0.39 3.81 ± 0.19 3.77 ± 0.29 3.73 ± 0.16
 Globulin mg/dL 3.05 ± 0.39 2.97 ± 0.21 3.17 ± 0.21 2.50 ± 0.35*
 Bilirubin
  Bilirubin (T) mg/dL 0.58 ± 0.13 0.67 ± 0.12 0.69 ± 0.15 0.84 ± 0.08**
  Bilirubin (D) mg/dL 0.14 ± 0.04 0.15 ± 0.04 0.17 ± 0.04 0.16 ± 0.04
 SGPT IU/L 51.60 ± 8.66 40.92 ± 5.63* 40.80 ± 5.88* 37.16 ± 6.29**
 SGOT IU/L 43.92 ± 5.92 42.29 ± 3.61 38.22 ± 2.76 33.39 ± 3.57**
 ALP IU/L 129.07 ± 10.45 125.25 ± 5.09 120.77 ± 4.41 119.81 ± 6.26
 Triglyceride (TG) mg/dL 73.27 ± 8.03 94.09 ± 9.05** 104.02 ± 9.35** 112.60 ± 9.99**
 Cholesterol
  Total cholesterol mg/dL 91.12 ± 8.67 105.89 ± 5.06** 115.15 ± 6.46** 114.02 ± 5.75**
  HDL cholesterol mg/dL 35.65 ± 4.54 36.33 ± 2.88 36.25 ± 2.87 40.72 ± 1.58*
  LDL cholesterol mg/dL 41.42 ± 4.46 43.53 ± 3.76 44.47 ± 1.84 46.11 ± 5.16
  VLDL cholesterol mg/dL 17.11 ± 2.54 18.03 ± 2.07 20.94 ± 3.04* 21.63 ± 2.40*
  1. Values are expressed as mean ± S.D. (n = 6). Statistical analysis done by one-way ANOVA followed by Dunnet’s t-test
  2. **P < 0.01 compared to control group
  3. *P < 0.05 compared to control group