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International Journal of Phytomedicine and Phytotherapy

Table 2 Mean pharmacokinetic parameters of Qu in plasma for 12 volunteers after intravenous administration of Corvitin® (average dose of anhydrous Qu was 44 mg)

From: UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration

Parameters Qu free Qu conjug Ir free Ir conjug Qu sum
Cmax (ng/ml) 2142 ± 419 1400 ± 941 252 ± 69 657 ± 359 3871 ± 1748
Tmax (h) 0.25 ± 0.00 0.42 ± 0.12 0.27 ± 0.07 0.46 ± 0.14 0.25 ± 0.00
AUC0–24 (h∙ng/ml) 545 ± 142 2344 ± 1251 83.24 ± 38.54 1155 ± 604 4137 ± 1796
AUC0–∞ (h∙ng/ml) 583.0 ± 91.8 2839 ± 1523 132.4 ± 28.1 1362 ± 670 4596 ± 2107
AUC0–24 /AUC0–∞ (per cent) 95.1 ± 6.0 82.9 ± 5.3 92.5 ± 4.0 84.3 ± 4.1 90.9 ± 3.6
K el 6.08 ± 2.47 0.11 ± 0.05 4.02 ± 0.68 0.19 ± 0.07 0.13 ± 0.03
T1/2 (h) 0.13 ± 0.06 6.90 ± 2.41 0.18 ± 0.03 4.40 ± 2.09 5.80 ± 1.45
  1. Mean ± S.D., n = 12