International Journal of Phytomedicine and Phytotherapy
Table 2 Mean pharmacokinetic parameters of Qu in plasma for 12 volunteers after intravenous administration of Corvitin® (average dose of anhydrous Qu was 44 mg)
From: UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
Parameters | Qu free | Qu conjug | Ir free | Ir conjug | Qu sum |
|---|---|---|---|---|---|
Cmax (ng/ml) | 2142 ± 419 | 1400 ± 941 | 252 ± 69 | 657 ± 359 | 3871 ± 1748 |
Tmax (h) | 0.25 ± 0.00 | 0.42 ± 0.12 | 0.27 ± 0.07 | 0.46 ± 0.14 | 0.25 ± 0.00 |
AUC0–24 (h∙ng/ml) | 545 ± 142 | 2344 ± 1251 | 83.24 ± 38.54 | 1155 ± 604 | 4137 ± 1796 |
AUC0–∞ (h∙ng/ml) | 583.0 ± 91.8 | 2839 ± 1523 | 132.4 ± 28.1 | 1362 ± 670 | 4596 ± 2107 |
AUC0–24 /AUC0–∞ (per cent) | 95.1 ± 6.0 | 82.9 ± 5.3 | 92.5 ± 4.0 | 84.3 ± 4.1 | 90.9 ± 3.6 |
K el | 6.08 ± 2.47 | 0.11 ± 0.05 | 4.02 ± 0.68 | 0.19 ± 0.07 | 0.13 ± 0.03 |
T1/2 (h) | 0.13 ± 0.06 | 6.90 ± 2.41 | 0.18 ± 0.03 | 4.40 ± 2.09 | 5.80 ± 1.45 |