Protective effect of crude sulphated polysaccharides from Sargassum Swartzii (Turn.) C.Ag. against acetaminophen induced liver toxicity in rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of Crude Sulphated Polysaccharides of Sargassum swartzii on Liver Enzymes and Bilirubin in Acetaminophen-Intoxicated Rats

Groups	ALT (U/L)	AST (U/L)	ALP (U/L)	LDH (U/L)	Bilirubin (mg/dl)
Normal control	27^d ± 1.7	88^d ± 8	45^c ± 6.2	238.6^d ± 10.2	0.56^c ± 0.051
Acetaminophen (AAP) control	64^a ± 7.8	187.6^a ± 9.29	124^a ± 4.3	542.6^a ± 17.6	0.93^a ± 0.054
Silymarin (35 mg/kg) + AAP	37.3^bc ± 4.5	139^bc ± 8.88	68.3^b ± 7.5	375^b ± 17.5	0.76^b ± 0.056
S. swartzii EW₁ + AAP	33.3^cd ± 2.5	121^c ± 12.5	47.6^c ± 1.5	318^c ± 10.5	0.76^b ± 0.06
S. swartzii EW₂ + AAP	45^b ± 4	154^b ± 14	60.3^b ± 0.57	375^b ± 17.5	0.73^b ± 0.052

The values are expressed as means ± Standard error (n = 6 animals per group)
The values having the same superscript within the column are not significantly (p < 0.05) different according to Duncan’s multiple range test