Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Dose-response characteristics of the influence of Annona muricata methanolic extracts on α-amylase activity

	Dose-Response characteristics		Sigmoid plot interpolation characteristics		Hyperbola plot interpolation characteristics		Michaelis-Menten’s kinetics		Straight line regression interpolation characteristics
	LogIC50	IC50	R²	Hill’s slope	Bmax	Kd	Km	Vmax	Y-intercept	slope
Fruit-pulp	0.335	2.163	0.927	5.029	40.67	−0.038	1.603 × 10⁻¹⁶	44.37	34.14	24.40
Leaf	0.266	1.846	0.966	4.832	46.41	−0.049	1.211 × 10⁻¹⁶	52.17	52.02	27.95
Stem-bark	0.265	1.843	0.983	4.447	45.83	−0.052	1.212 × 10⁻¹⁶	51.89	52.32	29.08
Root-bark	0.338	2.177	0.947	5.077	40.46	−0.037	1.264 × 10⁻¹⁶	44.08	37.93	24.22
Acarbose	0.236	1.722	0.996	3.695	51.17	−0.079	2.220 × 10⁻¹⁶	63.17	65.59	41.67

Bmax = maximum binding capacity (U/L), Kd = dissociation constant (mg/dL), Km = Michaelis-Menten’s constant (mg/dL) and Vmax = maximum velocity (U/L)