Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 Dose-response characteristics of the influence of Annona muricata dichloromethane extracts on α-amylase activity

	Dose-Response characteristics		Sigmoid plot interpolation characteristics		Hyperbola plot interpolation characteristics		Michaelis-Menten’s kinetics		Straight line regression interpolation characteristics
	LogIC50	IC50	R²	Hill’s slope	Bmax	Kd	Km	Vmax	Y-intercept	slope
Fruit-pulp	0.441	2.761	1.000	2.294	46.18	−0.054	1.182 × 10^− 16	52.51	52.61	52.32
Leaf	0.328	2.127	1.000	3.863	46.06	−0.044	1.259 × 10⁻¹⁶	51.07	51.17	51.83
Stem-bark	0.863	7.286	–	1.378	46.86	−0.061	2.098 × 10⁻¹⁶	54.32	54.42	53.26
Root-bark	0.931	8.528	–	1.418	46.07	−0.059	1.113 × 10⁻¹⁶	53.22	53.32	52.48
Acarbose	0.236	1.722	1.000	1.481	51.17	−0.079	2.220 × 10⁻¹⁶	63.07	65.59	41.67

Bmax = maximum binding capacity (U/L), Kd = dissociation constant (mg/dL), Km = Michaelis-Menten’s constant (mg/dL) and Vmax = maximum velocity (U/L)