Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of α-amylase and α-glucosidase activities

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 8 Dose-response characteristics of the influence of Annona muricata dichloromethane extracts on α-glucosidase activity

	Dose-Response characteristics		Sigmoid plot interpolation characteristics		Hyperbola plot interpolation characteristics		Michaelis-Menten’s kinetics		Straight line regression interpolation characteristics
	LogIC50	IC50	R²	Hill’s slope	Bmax	Kd	Km	Vmax	Y-intercept	slope
Fruit-pulp	1.445	27.86	–	1.068	46.18	−0.068	1.486 × 10⁻¹⁶	54.79	54.89	53.00
Leaf	0.857	7.188	–	1.325	47.43	−0.061	2.000 × 10⁻¹⁶	55.05	55.15	53.74
Stem-bark	1.253	17.91	–	1.144	46.69	−0.065	1.878 × 10⁻¹⁶	54.79	54.88	53.25
Root-bark	0.629	4.254	1.000	1.375	48.50	−0.065	1.642 × 10⁻¹⁶	57.02	57.12	55.15
Acarbose	0.236	1.722	1.000	1.481	51.17	−0.079	2.220 × 10⁻¹⁶	63.07	63.07	59.18

Bmax = maximum binding capacity (U/L), Kd = dissociation constant (mg/dL), Km = Michaelis-Menten’s constant (mg/dL) and Vmax = maximum velocity (U/L)