Table 3 Effect of methanolic extract fractions of LCME on different serum biochemical parameters in paracetamol induced hepatotoxicity in rats

Normal

62.18 ± 4.13

61.51 ± 5.89

442.5 ± 12.31

215.61 ± 6.81

3.83 ± 0.39

0.13 ± 0.003

0.04 ± 0.005

44.18 ± 4.84

7.81 ± 0.52

3.53 ± 0.32

14.16 ± 2.31

Toxic

145.16 ± 8.18

167.35 ± 6.29

852.15 ± 16.84

363.51 ± 7.16

31.38 ± 0.67

2.98 ± 0.21

1.32 ± 0.05

155.31 ± 10.18

4.01 ± 0.32

1.68 ± 0.14

149.19 ± 6.15

Silymarin 100 mg/kg

76.18 ± 1.37^***

(83.7%)

76.31 ± 4.12^***

(85.01%)

502.18 ± 12.4^***

(80.52%)

240.38 ± 4.93^***

(83%)

8.78 ± 1.32^***

(82.03%)

0.59 ± 0.02^***

(83.85%)

0.27 ± 0.005^***

(82.03%)

63.31 ± 4.93^***

(82.78%)

7.14 ± 0.56^***

(82.36%)

3.21 ± 0.16^***

(82.7%)

38.43 ± 3.16^***

(83.2%)

TLF-LCME 50

109.3 ± 6.81^***

(43.37%)

118.31 ± 4.32^***

(46.2%)

653.25 ± 11.38^***

(48.5%)

298.11 ± 4.87^***

(43.9%)

19.06 ± 2.31^***

(44.35%)

1.43 ± 0.04^***

(54.38%)

0.69 ± 0.02^***

(50.7%)

104.39 ± 10.14^***

(45.94%)

5.83 ± 0.71^***

(47.89%)

2.45 ± 0.51^***

(41.62%)

80.41 ± 3.65^***

(51.11%)

TLF-LCME 100

112.36 ± 7.23^***

(39.75%)

123.93 ± 6.72^***

(41.5%)

670.34 ± 12.98^***

(44.3%)

305.38 ± 7.63^***

(39.1%)

21.31 ± 3.16^***

(37.05%)

1.51 ± 0.01^***

(51.57%)

0.75 ± 0.05^***

(44.53%)

111.18 ± 11.3^***

(39.6%)

5.23 ± 0.81^***

(32.1%)

2.32 ± 0.19^***

(34.5%)

84.31 ± 4.51^***

(48.14%)

BNF-LCME 50

79.38 ± 7.19^***

(79.5%)

82.49 ± 2.28^***

(80.14%)

529.81 ± 11.34^***

(78.78%)

247.42 ± 5.31^***

(78.37%)

9.86 ± 1.16^***

(78.11%)

0.72 ± 0.02^***

(79.28%)

0.30 ± 0.002^***

(79.1%)

66.31 ± 4.76^***

(79.37%)

7.01 ± 0.64^***

(78.94%)

3.18 ± 0.11^***

(79.12%)

42.25 ± 4.46^***

(79.25%)

BNF-LCME 100

85.18 ± 4.34^***

(72.28%)

85.34 ± 5.45^***

(77.51%)

550.38 ± 4.81^***

(73.65%)

256.38 ± 6.18^***

(72.29%)

10.04 ± 1.38^***

(77.16%)

0.82 ± 0.05^***

(75.78%)

0.36 ± 0.05^***

(75%)

76.34 ± 5.62^***

(71.11%)

6.93 ± 0.59^***

(76.84%)

3.12 ± 0.23^***

(77.83%)

48.65 ± 3.12^***

(74.81%)

AQF-LCME 50

98.16 ± 5.74^***

(56.6%)

102.27 ± 6.63^***

(61.2%)

609.1 ± 12.19^***

(59.2%)

280.29 ± 5.18^***

(56.08%)

16.31 ± 2.51^***

(54.45%)

1.41 ± 0.03^***

(55.08%)

0.51 ± 0.05^***

(58.59%)

93.74 ± 4.83^***

(55.85%)

6.21 ± 0.53^***

(57.36%)

2.76 ± 0.51^***

(58.37%)

72.43 ± 6.31^***

(57.03%)

AQF-LCME 100

103.33 ± 4.38^***

(50.6%)

109.43 ± 5.49^***

(54.71%)

622.16 ± 11.47^***

(56.09%)

287.53 ± 6.17^***

(51.35%)

17.18 ± 3.36^***

(51.55%)

1.49 ± 0.03^***

(52.2%)

0.59 ± 0.003^***

(56.13%)

98.18 ± 3.36^***

(51.32%)

6.09 ± 0.11^***

(52.1%)

2.55 ± 0.41^***

(47.02%)

79.31 ± 5.56^***

(51.85%)