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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of methanolic extract fractions of LCME on different serum biochemical parameters in paracetamol induced hepatotoxicity in rats

From: Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

GROUPS AST
(U/l)
ALT
(U/l)
ALP
(U/l)
LDH
(U/l)
GGT
(U/l)
TB
(mg/dl)
DB
(mg/dl)
CHOL
(mg/dl)
TP
(g/dl)
ALB
(g/dl)
PT
(seconds)
Normal 62.18 ± 4.13 61.51 ± 5.89 442.5 ± 12.31 215.61 ± 6.81 3.83 ± 0.39 0.13 ± 0.003 0.04 ± 0.005 44.18 ± 4.84 7.81 ± 0.52 3.53 ± 0.32 14.16 ± 2.31
Toxic 145.16 ± 8.18 167.35 ± 6.29 852.15 ± 16.84 363.51 ± 7.16 31.38 ± 0.67 2.98 ± 0.21 1.32 ± 0.05 155.31 ± 10.18 4.01 ± 0.32 1.68 ± 0.14 149.19 ± 6.15
Silymarin 100 mg/kg 76.18 ± 1.37***
(83.7%)
76.31 ± 4.12***
(85.01%)
502.18 ± 12.4***
(80.52%)
240.38 ± 4.93***
(83%)
8.78 ± 1.32***
(82.03%)
0.59 ± 0.02***
(83.85%)
0.27 ± 0.005***
(82.03%)
63.31 ± 4.93***
(82.78%)
7.14 ± 0.56***
(82.36%)
3.21 ± 0.16***
(82.7%)
38.43 ± 3.16***
(83.2%)
TLF-LCME 50 109.3 ± 6.81***
(43.37%)
118.31 ± 4.32***
(46.2%)
653.25 ± 11.38***
(48.5%)
298.11 ± 4.87***
(43.9%)
19.06 ± 2.31***
(44.35%)
1.43 ± 0.04***
(54.38%)
0.69 ± 0.02***
(50.7%)
104.39 ± 10.14***
(45.94%)
5.83 ± 0.71***
(47.89%)
2.45 ± 0.51***
(41.62%)
80.41 ± 3.65***
(51.11%)
TLF-LCME 100 112.36 ± 7.23***
(39.75%)
123.93 ± 6.72***
(41.5%)
670.34 ± 12.98***
(44.3%)
305.38 ± 7.63***
(39.1%)
21.31 ± 3.16***
(37.05%)
1.51 ± 0.01***
(51.57%)
0.75 ± 0.05***
(44.53%)
111.18 ± 11.3***
(39.6%)
5.23 ± 0.81***
(32.1%)
2.32 ± 0.19***
(34.5%)
84.31 ± 4.51***
(48.14%)
BNF-LCME 50 79.38 ± 7.19***
(79.5%)
82.49 ± 2.28***
(80.14%)
529.81 ± 11.34***
(78.78%)
247.42 ± 5.31***
(78.37%)
9.86 ± 1.16***
(78.11%)
0.72 ± 0.02***
(79.28%)
0.30 ± 0.002***
(79.1%)
66.31 ± 4.76***
(79.37%)
7.01 ± 0.64***
(78.94%)
3.18 ± 0.11***
(79.12%)
42.25 ± 4.46***
(79.25%)
BNF-LCME 100 85.18 ± 4.34***
(72.28%)
85.34 ± 5.45***
(77.51%)
550.38 ± 4.81***
(73.65%)
256.38 ± 6.18***
(72.29%)
10.04 ± 1.38***
(77.16%)
0.82 ± 0.05***
(75.78%)
0.36 ± 0.05***
(75%)
76.34 ± 5.62***
(71.11%)
6.93 ± 0.59***
(76.84%)
3.12 ± 0.23***
(77.83%)
48.65 ± 3.12***
(74.81%)
AQF-LCME 50 98.16 ± 5.74***
(56.6%)
102.27 ± 6.63***
(61.2%)
609.1 ± 12.19***
(59.2%)
280.29 ± 5.18***
(56.08%)
16.31 ± 2.51***
(54.45%)
1.41 ± 0.03***
(55.08%)
0.51 ± 0.05***
(58.59%)
93.74 ± 4.83***
(55.85%)
6.21 ± 0.53***
(57.36%)
2.76 ± 0.51***
(58.37%)
72.43 ± 6.31***
(57.03%)
AQF-LCME 100 103.33 ± 4.38***
(50.6%)
109.43 ± 5.49***
(54.71%)
622.16 ± 11.47***
(56.09%)
287.53 ± 6.17***
(51.35%)
17.18 ± 3.36***
(51.55%)
1.49 ± 0.03***
(52.2%)
0.59 ± 0.003***
(56.13%)
98.18 ± 3.36***
(51.32%)
6.09 ± 0.11***
(52.1%)
2.55 ± 0.41***
(47.02%)
79.31 ± 5.56***
(51.85%)
  1. Data expressed as mean ± SD, n = 6, values in parenthesis indicate percentage recovery
  2. TLF-LCME Toulene fraction of methanolic extract fraction of Lindernia ciliata, BNF-LCME Butanone fraction of methanolic extract fraction of Lindernia ciliata, AQF-LCME Aqueous fraction of methanolic extract fraction of Lindernia ciliata
  3. p value-paracetamol Vs vehicle; p value paracetamol Vs treatments- * < 0.05; ** < 0.01; *** < 0.001