International Journal of Phytomedicine and Phytotherapy
Table 4 Effect of BNF-LCME on different serum biochemical parameters and prothrombin time in D-galactosamine induced hepatotoxicity in rats
Groups | Glucose (U/L) | AST (U/L) | ALT (U/L) | ALP (U/L) | TB (mg/dL) | DB (mg/dL) | TP (g/dL) | ALB (g/dL) | LDH (U/L) | PT (seconds) |
|---|---|---|---|---|---|---|---|---|---|---|
Normal | 91.6 ± 3.3 | 60.3 ± 3.1 | 58.1 ± 4.3 | 523 ± 9.71 | 0.19 ± 0.05 | 0.04 ± 0.005 | 7.91 ± 0.31 | 3.86 ± 0.22 | 212.73 ± 6.72 | 14.35 ± 2.15 |
Toxic | 48..3 ± 1.9 | 241.4 ± 3.7 | 186.3 ± 5.1 | 967.3 ± 10.3 | 2.81 ± 0.13 | 1.14 ± 0.08 | 4.61 ± 0.44 | 2.01 ± 0.12 | 396.11 ± 8.13 | 162.21 ± 3.4 |
Silymarin 100 mg/kg | 84.6 ± 3.5*** 83.83% | 89.1 ± 5.6*** 84.09% | 78.1 ± 3.6*** 84.33% | 602.1 ± 6.78*** 82.12% | 0.62 ± 0.005*** 83.58% | 0.22 ± 0.005*** 86.63% | 7.25± 0.13*** 80.78% | 3.465 ± 0.55*** 78.36% | 241.33 ± 7.61*** 83.82% | 38.31 ± 2.64*** 83.4% |
BNF-LCME 50 | 77.5 ± 1.8*** 67.45% | 93.6 ± 1.9*** 81.69% | 82.3 ± 4.8*** 81.12% | 623 ± 7.31*** 77.22% | 0.68 ± 0.04*** 81.29% | 0.26 ± 0.06*** 80.01% | 7.19 ± 0.21*** 78.81% | 3.38 ± 0.19*** 74.35% | 251.64 ± 6.35*** 78.80% | 41.45 ± 2.86*** 81.6% |
BNF-LCME 100 | 75.3 ± 3.6*** 62.5% | 99.1 ± 3.2*** 78.57% | 89.3 ± 7.6*** 75.66% | 637.1 ± 8.91*** 74.31% | 0.76 ± 0.05*** 78.24% | 0.29 ± 0.001*** 77.27% | 6.93 ± 0.37*** 70.3% | 3.16 ± 0.25*** 62.5 | 259.38 ± 6.5*** 74.2 | 48.34 ± 2.96*** 77.01 |