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International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of BNF-LCME on different serum biochemical parameters and prothrombin time in D-galactosamine induced hepatotoxicity in rats

From: Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Groups Glucose
(U/L)
AST
(U/L)
ALT
(U/L)
ALP
(U/L)
TB
(mg/dL)
DB
(mg/dL)
TP
(g/dL)
ALB
(g/dL)
LDH
(U/L)
PT
(seconds)
Normal 91.6 ± 3.3 60.3 ± 3.1 58.1 ± 4.3 523 ± 9.71 0.19 ± 0.05 0.04 ± 0.005 7.91 ± 0.31 3.86 ± 0.22 212.73 ± 6.72 14.35 ± 2.15
Toxic 48..3 ± 1.9 241.4 ± 3.7 186.3 ± 5.1 967.3 ± 10.3 2.81 ± 0.13 1.14 ± 0.08 4.61 ± 0.44 2.01 ± 0.12 396.11 ± 8.13 162.21 ± 3.4
Silymarin 100 mg/kg 84.6 ± 3.5***
83.83%
89.1 ± 5.6***
84.09%
78.1 ± 3.6***
84.33%
602.1 ± 6.78***
82.12%
0.62 ± 0.005***
83.58%
0.22 ± 0.005***
86.63%
7.25±
0.13***
80.78%
3.465 ± 0.55***
78.36%
241.33 ± 7.61***
83.82%
38.31 ± 2.64***
83.4%
BNF-LCME 50 77.5 ± 1.8***
67.45%
93.6 ± 1.9***
81.69%
82.3 ± 4.8***
81.12%
623 ± 7.31***
77.22%
0.68 ± 0.04***
81.29%
0.26 ± 0.06***
80.01%
7.19 ± 0.21***
78.81%
3.38 ± 0.19***
74.35%
251.64 ± 6.35***
78.80%
41.45 ± 2.86***
81.6%
BNF-LCME 100 75.3 ± 3.6***
62.5%
99.1 ± 3.2***
78.57%
89.3 ± 7.6***
75.66%
637.1 ± 8.91***
74.31%
0.76 ± 0.05***
78.24%
0.29 ± 0.001***
77.27%
6.93 ± 0.37***
70.3%
3.16 ± 0.25***
62.5
259.38 ± 6.5***
74.2
48.34 ± 2.96***
77.01
  1. Data expressed as mean ± SD, n = 6, values in parenthesis indicate percentage recovery
  2. p value- D-galactosamine Vs vehicle; p value D-galactosamine Vs treatments- * < 0.05; ** < 0.01; *** < 0.001
  3. BNF-LCME Butanone fraction of methanolic extract of Lindernia ciliata