Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 7 Results of the analgesic activity of the total ethanol extract and the different fractions of C. myxa L. leaves in mice using the hot plate method using paracetamol as a standard

From: Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves

Group Time (sec)
0 h 30 min 1 h 2 h 3 h 4 h 5 h
Control (−ve) 87.00 ± 8.32 83.67 ± 7.57 80.33 ± 4.16 69.67 ± 4.16 70.00 ± 3.61 80.67 ± 4.73 81.67 ± 3.06
Total extract (350 mg/kg) 75.67 ± 11.68 94.33 ± 7.23 106.33 ± 3.06*** 130.67 ± 18.50** 140.67 ± 10.60*** 128.33 ± 21.20* 101.33 ± 4.93**
Petroleum ether fraction (350 mg/kg) 72.00 ± 6.56 * 100.33 ± 4.16* 191.00 ± 31.08** 270.67 ± 8.50*** 289.00 ± 3.00*** 227.00 ± 28.84* 99.00 ± 10.00*
Dichloromethane fraction (350 mg/kg) 78.67 ± 10.60 86.67 ± 8.08 170.33 ± 21.39** 206.33 ± 16.29*** 288.33 ± 20.82*** 199.67 ± 9.87*** 89.00 ± 13.86
Ethyl acetate fraction (350 mg/kg) 71.00 ± 10.58 91.67 ± 3.06 107.33 ± 11.93* 129.67 ± 2.08*** 139.33 ± 5.69*** 103.33 ± 1.53** 91.33 ± 12.42
Butanol fraction (350 mg/kg) 65.00 ± 8.00 ** 83.33 ± 7.37 85.67 ± 13.01 74.33 ± 5.03 74.33 ± 5.03 79.67 ± 2.03 80.33 ± 4.62
Paracetamol (100 mg/kg) 70.67 ± 5.51** 107.67 ± 5.77* 311.00 ± 19.28*** 321.67 ± 25.01*** 386.33 ± 8.08*** 258.33 ± 41.59*** 122.33 ± 15.01**
  1. The results are presented as the mean ± S.E.M. Differences with respect to the control group were calculated using the student’s T-test (*P > 0.05, **P < 0.01, ***P < 0.001)