Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 7 Results of the analgesic activity of the total ethanol extract and the different fractions of C. myxa L. leaves in mice using the hot plate method using paracetamol as a standard

Group	Time (sec)
Group	0 h	30 min	1 h	2 h	3 h	4 h	5 h
Control (−ve)	87.00 ± 8.32	83.67 ± 7.57	80.33 ± 4.16	69.67 ± 4.16	70.00 ± 3.61	80.67 ± 4.73	81.67 ± 3.06
Total extract (350 mg/kg)	75.67 ± 11.68	94.33 ± 7.23	106.33 ± 3.06^***	130.67 ± 18.50^**	140.67 ± 10.60^***	128.33 ± 21.20^*	101.33 ± 4.93^**
Petroleum ether fraction (350 mg/kg)	72.00 ± 6.56 ^*	100.33 ± 4.16^*	191.00 ± 31.08^**	270.67 ± 8.50^***	289.00 ± 3.00^***	227.00 ± 28.84^*	99.00 ± 10.00^*
Dichloromethane fraction (350 mg/kg)	78.67 ± 10.60	86.67 ± 8.08	170.33 ± 21.39^**	206.33 ± 16.29^***	288.33 ± 20.82^***	199.67 ± 9.87^***	89.00 ± 13.86
Ethyl acetate fraction (350 mg/kg)	71.00 ± 10.58	91.67 ± 3.06	107.33 ± 11.93^*	129.67 ± 2.08^***	139.33 ± 5.69^***	103.33 ± 1.53^**	91.33 ± 12.42
Butanol fraction (350 mg/kg)	65.00 ± 8.00 ^**	83.33 ± 7.37	85.67 ± 13.01	74.33 ± 5.03	74.33 ± 5.03	79.67 ± 2.03	80.33 ± 4.62
Paracetamol (100 mg/kg)	70.67 ± 5.51^**	107.67 ± 5.77^*	311.00 ± 19.28^***	321.67 ± 25.01^***	386.33 ± 8.08^***	258.33 ± 41.59^***	122.33 ± 15.01^**

The results are presented as the mean ± S.E.M. Differences with respect to the control group were calculated using the student’s T-test (*P > 0.05, **P < 0.01, ***P < 0.001)