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International Journal of Phytomedicine and Phytotherapy

Table 5 Effect of EETI on Yeast-induced pyrexia in mice

From: In vivo and in vitro pharmacological activities of Tacca integrifolia rhizome and investigation of possible lead compounds against breast cancer through in silico approaches

GroupsDose
(mg/kg)
Rectal temperature (°C)
Normal (A) (Before yeast injection)After administration of drug
after 24 h (B)1st h (C1)2nd h (C2)3rd h (C3)4th h (C4)
Control10 mL36.65 ± 0.1038.91 ± 0.3338.81 ± 0.2038.77 ± 0.1038.67 ± 0.1938.68 ± 0.20
Paracetamol15037.07 ± 0.0739.45 ± 0.0638.19 ± 0.02**37.82 ± 0.05**37.30 ± 0.01**37.34 ± 0.27**
EETI20037.04 ± 0.0539.72 ± 0.4539.42 ± 0.2538.98 ± 0.21*38.02 ± 0.12**38.03 ± 0.14**
EETI40037.02 ± 0.1039.82 ± 0.2139.32 ± 0.3338.72 ± 0.13*37.65 ± 0.45**37.72 ± 0.11**
  1. SEM standard error of mean, n = 5, where n is the number of mice. Values in the figure are expressed as mean ± SEM, *p < 0.05, **p < 0.01 significantly different in comparison with control. The data was analyzed by ANOVA followed by Dunnett’s test