In vivo and in vitro pharmacological activities of Tacca integrifolia rhizome and investigation of possible lead compounds against breast cancer through in silico approaches

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 5 Effect of EETI on Yeast-induced pyrexia in mice

Groups	Dose (mg/kg)	Rectal temperature (°C)
		Normal (A) (Before yeast injection)	After administration of drug
		Normal (A) (Before yeast injection)	after 24 h (B)	1st h (C1)	2nd h (C2)	3rd h (C3)	4th h (C4)
Control	10 mL	36.65 ± 0.10	38.91 ± 0.33	38.81 ± 0.20	38.77 ± 0.10	38.67 ± 0.19	38.68 ± 0.20
Paracetamol	150	37.07 ± 0.07	39.45 ± 0.06	38.19 ± 0.02**	37.82 ± 0.05**	37.30 ± 0.01**	37.34 ± 0.27**
EETI	200	37.04 ± 0.05	39.72 ± 0.45	39.42 ± 0.25	38.98 ± 0.21*	38.02 ± 0.12**	38.03 ± 0.14**
EETI	400	37.02 ± 0.10	39.82 ± 0.21	39.32 ± 0.33	38.72 ± 0.13*	37.65 ± 0.45**	37.72 ± 0.11**

SEM standard error of mean, n = 5, where n is the number of mice. Values in the figure are expressed as mean ± SEM, *p < 0.05, **p < 0.01 significantly different in comparison with control. The data was analyzed by ANOVA followed by Dunnett’s test