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International Journal of Phytomedicine and Phytotherapy

Table 10 Oral Hypoglycaemic activity of methanolic extract of A. solanacea and its n-hexane soluble fraction

From: In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

Animal group

Dose Mg/kg

Mean ± SEM

0 Minute

30 Minute

90 Minute

120 Minute

Control

(Normal Saline)

 

6.64 ± 0.44

14.08 ± 0.12

(+ 112.05)a

8.98 ± 0.89

(− 36.22)b

6.76 ± 0.33

(− 52)b

Standard (Glibenclamide)

10

5.82 ± 0.32

10.06 ± 0.73*

(+ 72.85)a

4.6 ± 0.20##

(− 54.27)b

4.18 ± 0.24##

(− 58.45)b

ASME

200

6.42 ± 0.31

10.16 ± 0.37*

(+ 58.25)a

4.68 ± 0.14##

(− 53.94)b

4.4 ± 0.10##

(− 56.69)b

ASNH

200

6.96 ± 0.24

10.80 ± 0.33

(+ 55.17)a

5.6 ± 0.36#

(− 48.15)b

4.74 ± 0.24##

(− 58.62)b

  1. Figures in parentheses are the % increase (+) or decrease (−) glucose level; a = compared to the glucose level at zero time, b = compared to the glucose level at 30 min after the glucose load, ASME = Methanolic extract of A. solanacea, ASNH = n-hexane soluble fraction. Each value represents the mean ± SEM. (n = 5). One- way ANOVA followed by Dunnett’s t test. ##p < 0.005, #p < 0.01, *p < 0.05 compared with control