In vivo and in silico evaluation of analgesic activity of Lippia alba

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effects of different extracts of L. alba in acetic acid-induced writhing test

Treatment group	Dose	n	Number of writhing	Inhibition (%)
Control	10 ml/kg	5	56.5 ± 5.80	–
Standard (Diclofenac Sodium)	100 mg/kg	5	10.75 ± 3.83*	78.61 ± 9.60*
ME	250 mg/kg	5	37.50 ± 1.70*^a	31.94 ± 5.80*
ME	500 mg/kg	5	27.00 ± 1.87*^a	49.30 ± 9.48*
PEE	250 mg/kg	5	36.25 ± 0.85*^a	33.89 ± 6.40*
PEE	500 mg/kg	5	26.00 ± 1.35*^a	53.09 ± 2.87*
DCME	250 mg/kg	5	37.5 ± 2.10*^a	30.89 ± 9.80*
DCME	500 mg/kg	5	27.50 ± 1.19*^a	50.09 ± 4.24*

Number of writhing is present as mean ± standard error of mean. *P < 0.05, vs control (Dunnett’s t test); ^aP < 0.05, vs Standard group (pair-wise comparison by post-hoc Tukey’s HSD test). ME: methanolic extract; PEE: petroleum ether extract; DCME: dichloromethane extract